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                                                                |  Gene description for Lrrc8b |  
                                                                    | Gene name | leucine rich repeat containing 8 family, member B |  
                                                                    | Gene symbol | Lrrc8b |  
                                                                    | Other names/aliases | R75581 Ta-lrrp
 mKIAA0231
 |  
                                                                    | Species | Mus musculus |  |  Database cross references - Lrrc8b |  
                                                                        | ExoCarta | ExoCarta_433926 |  
                                                                        | Vesiclepedia | VP_433926 |  
                                                                        | Entrez Gene | 433926 |  
                                                                            | UniProt | Q5DU41 |  |  Lrrc8b identified in sEVs derived from the following tissue/cell type |  
                                                                                | Melanoma cells | 34957415   |  
                                                                                | Melanoma cells | 34957415   |  
                                                                
                                                                    |  Gene ontology annotations for Lrrc8b |  
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                                                                |  Experiment description  of studies that identified Lrrc8b in sEVs |  
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                                                                                            | 1 | 
                                                                                                    
                                                                                                        | Experiment ID | 1117 | 
                                                                                                                
                                                                                                                    | MISEV standards |  
                                                                                                                    | ✘ | Biophysical techniques |  
                                                                                                                    | ✔ 
                                                                                                                                Cd81|Icam1
                                                                                                                             | Enriched markers |  
                                                                                                                    | ✘ | Negative markers |  
                                                                                                                    | ✔ 
                                                                                                                                NTA
                                                                                                                             | Particle analysis |  |  
                                                                                                        | Identified molecule | protein   |  
                                                                                                        | Identification method | Mass spectrometry |  
                                                                                                        | PubMed ID | 34957415   |  
                                                                                                        | Organism | Mus musculus |  
                                                                                                        | Experiment description | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism |  
                                                                                                        | Authors | "GarcÃa-Silva S, Benito-MartÃn A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÃ, Torres-Ruiz R, RodrÃguez-Perales S, MartÃnez L, Pérez-MartÃnez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, MartÃnez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, MegÃas D, Mehrara BJ, Lyden D, Peinado H." |  
                                                                                                        | Journal name | Nat Cancer |  
                                                                                                        | Publication year | 2021 |  
                                                                                                        | Sample | Melanoma cells |  
                                                                                                        | Sample name | B16-F1R2 |  
                                                                                                        | Isolation/purification methods | Differential centrifugation Ultracentrifugation
 |  
                                                                                                        | Flotation density | - |  
                                                                                                        | Molecules identified in the study | Protein |  
                                                                                                        | Methods used in the study | Western blotting Mass spectrometry
 |  |  |  
                                                                                | 
                                                                                        
                                                                                            | 2 | 
                                                                                                    
                                                                                                        | Experiment ID | 1118 | 
                                                                                                                
                                                                                                                    | MISEV standards |  
                                                                                                                    | ✘ | Biophysical techniques |  
                                                                                                                    | ✔ 
                                                                                                                                Cd81|Icam1
                                                                                                                             | Enriched markers |  
                                                                                                                    | ✘ | Negative markers |  
                                                                                                                    | ✔ 
                                                                                                                                NTA
                                                                                                                             | Particle analysis |  |  
                                                                                                        | Identified molecule | protein   |  
                                                                                                        | Identification method | Mass spectrometry |  
                                                                                                        | PubMed ID | 34957415   |  
                                                                                                        | Organism | Mus musculus |  
                                                                                                        | Experiment description | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism |  
                                                                                                        | Authors | "GarcÃa-Silva S, Benito-MartÃn A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÃ, Torres-Ruiz R, RodrÃguez-Perales S, MartÃnez L, Pérez-MartÃnez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, MartÃnez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, MegÃas D, Mehrara BJ, Lyden D, Peinado H." |  
                                                                                                        | Journal name | Nat Cancer |  
                                                                                                        | Publication year | 2021 |  
                                                                                                        | Sample | Melanoma cells |  
                                                                                                        | Sample name | B16-F1R2 |  
                                                                                                        | Isolation/purification methods | Differential centrifugation Ultracentrifugation
 |  
                                                                                                        | Flotation density | - |  
                                                                                                        | Molecules identified in the study | Protein |  
                                                                                                        | Methods used in the study | Western blotting Mass spectrometry
 |  |  |  
                                                            
                                                                
                                                                    
                                                                        
                                                                            |  Protein-protein interactions for Lrrc8b |  
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                                                                        |  Pathways in which Lrrc8b is involved |  
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