Gene description for Cortactin
Gene name CG3637 gene product from transcript CG3637-RD
Gene symbol Cortactin
Other names/aliases CG3637
DmelCG3637
cortactin
cttn
Species Drosophila melanogaster
 Database cross references - Cortactin
ExoCarta ExoCarta_42491
Vesiclepedia VP_42491
Entrez Gene 42491
 Cortactin identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Cortactin
Molecular Function
    proline-rich region binding GO:0070064 IGI
Biological Process
    border follicle cell migration GO:0007298 IMP
    female germline ring canal formation GO:0007301 IMP
    positive regulation of receptor-mediated endocytosis GO:0048260 IGI
    protein localization to actin cytoskeleton GO:1903119 IMP
    positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    lamellipodium GO:0030027 IDA
    actin cap GO:0030478 IDA
    protein-containing complex GO:0032991 IPI
    sperm individualization complex GO:0070864 IDA
 Experiment description of studies that identified Cortactin in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cortactin
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 dbo  
Two-hybrid Drosophila melanogaster
2 CG18748  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Cortactin is involved
No pathways found





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