Gene description for MEP1B
Gene name meprin A, beta
Gene symbol MEP1B
Other names/aliases -
Species Homo sapiens
 Database cross references - MEP1B
ExoCarta ExoCarta_4225
Vesiclepedia VP_4225
Entrez Gene 4225
HGNC 7020
MIM 600389
UniProt Q16820  
 MEP1B identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 25890246    
 Gene ontology annotations for MEP1B
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    proteolysis GO:0006508 IEA
    inflammatory response GO:0006954 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IDA
    meprin A complex GO:0017090 IDA
 Experiment description of studies that identified MEP1B in sEVs
1
Experiment ID 283
MISEV standards
CEM
Biophysical techniques
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
Negative markers
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for MEP1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ALK 238
Affinity Capture-MS Homo sapiens
2 GAST  
Biochemical Activity Homo sapiens
3 FN1 2335
Biochemical Activity Homo sapiens
4 PYY  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which MEP1B is involved
No pathways found





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