Gene description for HSPA5
Gene name heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Gene symbol HSPA5
Other names/aliases grp78
Species Bos taurus
 Database cross references - HSPA5
ExoCarta ExoCarta_415113
Vesiclepedia VP_415113
Entrez Gene 415113
UniProt Q0VCX2  
 HSPA5 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for HSPA5
Molecular Function
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    heat shock protein binding GO:0031072 IEA
    unfolded protein binding GO:0051082 IEA
    misfolded protein binding GO:0051787 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    cellular response to unfolded protein GO:0034620 IEA
    protein refolding GO:0042026 IEA
    chaperone cofactor-dependent protein refolding GO:0051085 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    endoplasmic reticulum lumen GO:0005788 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum chaperone complex GO:0034663 IEA
 Experiment description of studies that identified HSPA5 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSPA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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