Gene description for HSPA5
Gene name heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Gene symbol HSPA5
Other names/aliases grp78
Species Bos taurus
 Database cross references - HSPA5
ExoCarta ExoCarta_415113
Vesiclepedia VP_415113
Entrez Gene 415113
UniProt Q0VCX2  
 HSPA5 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for HSPA5
Molecular Function
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    heat shock protein binding GO:0031072 IEA
    unfolded protein binding GO:0051082 IEA
    misfolded protein binding GO:0051787 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    cellular response to unfolded protein GO:0034620 IEA
    protein refolding GO:0042026 IEA
    chaperone cofactor-dependent protein refolding GO:0051085 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    endoplasmic reticulum lumen GO:0005788 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum chaperone complex GO:0034663 IEA
 Experiment description of studies that identified HSPA5 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSPA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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