Gene description for alphaCOP
Gene name Coat Protein (coatomer) alpha
Gene symbol alphaCOP
Other names/aliases CG7961
DmelCG7961
alpha-COP
alphaCop
Species Drosophila melanogaster
 Database cross references - alphaCOP
ExoCarta ExoCarta_38199
Vesiclepedia VP_38199
Entrez Gene 38199
 alphaCOP identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for alphaCOP
Biological Process
    male meiosis cytokinesis GO:0007112 IMP
    regulation of lipid storage GO:0010883 IDA
    vesicle-mediated transport GO:0016192 NAS
    protein localization to cleavage furrow GO:1905345 IMP
Subcellular Localization
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    COPI vesicle coat GO:0030126 IDA
 Experiment description of studies that identified alphaCOP in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for alphaCOP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NimC1  
Two-hybrid Drosophila melanogaster
2 Sce  
Two-hybrid Drosophila melanogaster
3 epsilonCOP  
Two-hybrid Drosophila melanogaster
4 CG7878  
Affinity Capture-MS Drosophila melanogaster
5 Mst84Dc  
Two-hybrid Drosophila melanogaster
6 betaCOP  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which alphaCOP is involved
No pathways found





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