Gene description for Naaladl1
Gene name N-acetylated alpha-linked acidic dipeptidase-like 1
Gene symbol Naaladl1
Other names/aliases Gm964
Naaladasel
Species Mus musculus
 Database cross references - Naaladl1
ExoCarta ExoCarta_381204
Vesiclepedia VP_381204
Entrez Gene 381204
UniProt Q7M758  
 Naaladl1 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Naaladl1
Molecular Function
    aminopeptidase activity GO:0004177 ISO
    aminopeptidase activity GO:0004177 ISS
    carboxypeptidase activity GO:0004180 IBA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    metallopeptidase activity GO:0008237 IEA
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
Biological Process
    proteolysis GO:0006508 IEA
    peptide catabolic process GO:0043171 ISO
    peptide catabolic process GO:0043171 ISS
Subcellular Localization
    cellular_component GO:0005575 ND
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
 Experiment description of studies that identified Naaladl1 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Naaladl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Naaladl1 is involved
No pathways found





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