Gene description for SLC27A1
Gene name solute carrier family 27 (fatty acid transporter), member 1
Gene symbol SLC27A1
Other names/aliases ACSVL5
FATP
FATP-1
FATP1
Species Homo sapiens
 Database cross references - SLC27A1
ExoCarta ExoCarta_376497
Vesiclepedia VP_376497
Entrez Gene 376497
HGNC 10995
MIM 600691
UniProt Q6PCB7  
 SLC27A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC27A1
Molecular Function
    nucleotide binding GO:0000166 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 ISS
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IDA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IMP
    protein binding GO:0005515 IPI
    biotin transmembrane transporter activity GO:0015225 IDA
    fatty acid transmembrane transporter activity GO:0015245 TAS
    efflux transmembrane transporter activity GO:0015562 IDA
    efflux transmembrane transporter activity GO:0015562 IMP
    very long-chain fatty acid-CoA ligase activity GO:0031957 IEA
    identical protein binding GO:0042802 IEA
    protein serine/threonine kinase activator activity GO:0043539 IEA
    arachidonate-CoA ligase activity GO:0047676 IEA
    oleoyl-CoA ligase activity GO:0090434 IBA
    oleoyl-CoA ligase activity GO:0090434 ISS
    oleate transmembrane transporter activity GO:1901480 IEA
Biological Process
    medium-chain fatty acid transport GO:0001579 IBA
    long-chain fatty acid metabolic process GO:0001676 IBA
    phosphatidylethanolamine biosynthetic process GO:0006646 IMP
    phosphatidic acid biosynthetic process GO:0006654 IMP
    phosphatidylglycerol biosynthetic process GO:0006655 IMP
    phosphatidylcholine biosynthetic process GO:0006656 IMP
    phosphatidylserine biosynthetic process GO:0006659 IMP
    phosphatidylinositol biosynthetic process GO:0006661 IMP
    response to cold GO:0009409 IEA
    positive regulation of triglyceride biosynthetic process GO:0010867 ISS
    biotin transport GO:0015878 IDA
    long-chain fatty acid transport GO:0015909 IDA
    long-chain fatty acid transport GO:0015909 IMP
    long-chain fatty acid transport GO:0015909 TAS
    long-chain fatty acid import across plasma membrane GO:0015911 IDA
    long-chain fatty acid import across plasma membrane GO:0015911 IMP
    positive regulation of heat generation GO:0031652 IEA
    cardiolipin biosynthetic process GO:0032049 IMP
    adiponectin-activated signaling pathway GO:0033211 IEA
    glucose import in response to insulin stimulus GO:0044381 ISS
    long-chain fatty acid import into cell GO:0044539 IBA
    long-chain fatty acid import into cell GO:0044539 IMP
    long-chain fatty acid import into cell GO:0044539 ISS
    negative regulation of phospholipid biosynthetic process GO:0071072 IMP
    export across plasma membrane GO:0140115 IDA
    export across plasma membrane GO:0140115 IMP
    transport across blood-brain barrier GO:0150104 NAS
    biotin import across plasma membrane GO:1905135 IDA
    lipid transport across blood-brain barrier GO:1990379 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 ISS
    membrane GO:0016020 HDA
 Experiment description of studies that identified SLC27A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC27A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 CA6 765
Affinity Capture-MS Homo sapiens
3 LGR4 55366
Affinity Capture-MS Homo sapiens
4 RPE65  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 SLC39A4 55630
Affinity Capture-MS Homo sapiens
6 LDLRAD1  
Affinity Capture-MS Homo sapiens
7 PEX19 5824
Affinity Capture-MS Homo sapiens
8 ZDHHC12  
Affinity Capture-MS Homo sapiens
9 CHRNA1  
Affinity Capture-MS Homo sapiens
10 TSPAN15 23555
Affinity Capture-MS Homo sapiens
11 LPAR2 9170
Affinity Capture-MS Homo sapiens
12 CD79A  
Affinity Capture-MS Homo sapiens
13 FFAR1  
Affinity Capture-MS Homo sapiens
14 SLC22A9  
Affinity Capture-MS Homo sapiens
15 SYP  
Affinity Capture-MS Homo sapiens
16 EVA1C  
Affinity Capture-MS Homo sapiens
17 C1orf210  
Affinity Capture-MS Homo sapiens
18 PBXIP1 57326
Affinity Capture-MS Homo sapiens
19 GPR182  
Affinity Capture-MS Homo sapiens
20 ITM2C 81618
Affinity Capture-MS Homo sapiens
21 PIGH  
Affinity Capture-MS Homo sapiens
22 C3orf52  
Affinity Capture-MS Homo sapiens
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