Gene description for Derl1
Gene name derlin 1
Gene symbol Derl1
Other names/aliases RGD1311835
Species Rattus norvegicus
 Database cross references - Derl1
ExoCarta ExoCarta_362912
Vesiclepedia VP_362912
Entrez Gene 362912
 Derl1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Derl1
Molecular Function
    protease binding GO:0002020 ISO
    signal recognition particle binding GO:0005047 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    MHC class I protein binding GO:0042288 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
    ATPase binding GO:0051117 ISO
    ubiquitin-specific protease binding GO:1990381 ISO
Biological Process
    response to unfolded protein GO:0006986 ISO
    endoplasmic reticulum unfolded protein response GO:0030968 ISO
    retrograde protein transport, ER to cytosol GO:0030970 ISO
    retrograde protein transport, ER to cytosol GO:0030970 ISO
    positive regulation of protein ubiquitination GO:0031398 ISO
    protein destabilization GO:0031648 ISO
    cellular response to unfolded protein GO:0034620 ISO
    ERAD pathway GO:0036503 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    cellular response to misfolded protein GO:0071218 ISO
Subcellular Localization
    early endosome GO:0005769 ISO
    late endosome GO:0005770 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    membrane GO:0016020 ISO
    Derlin-1-VIMP complex GO:0036502 ISO
    Derlin-1 retrotranslocation complex GO:0036513 ISO
    endoplasmic reticulum quality control compartment GO:0044322 ISO
 Experiment description of studies that identified Derl1 in sEVs
1
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Derl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cacna1c  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Derl1 is involved
No pathways found





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