Gene description for Sppl2b
Gene name	signal peptide peptidase-like 2B
Gene symbol	Sppl2b
Other names/aliases	RGD1308556
Species	Rattus norvegicus
Database cross references - Sppl2b
ExoCarta	ExoCarta_362828
Vesiclepedia	VP_362828
Entrez Gene	362828
UniProt	Q5PQL3
Sppl2b identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Sppl2b

Molecular Function     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IBA     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IEA     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISO     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISO     aspartic endopeptidase activity, intramembrane cleaving GO:0042500 ISS     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS Biological Process     membrane protein ectodomain proteolysis GO:0006509 IEA     membrane protein ectodomain proteolysis GO:0006509 ISO     membrane protein ectodomain proteolysis GO:0006509 ISS     membrane protein intracellular domain proteolysis GO:0031293 IEA     membrane protein intracellular domain proteolysis GO:0031293 ISO     membrane protein intracellular domain proteolysis GO:0031293 ISS     membrane protein proteolysis GO:0033619 IBA     membrane protein proteolysis GO:0033619 ISO     membrane protein proteolysis GO:0033619 ISS     regulation of immune response GO:0050776 IEA     regulation of immune response GO:0050776 ISO     regulation of immune response GO:0050776 ISS Subcellular Localization     Golgi membrane GO:0000139 IEA     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     lysosomal membrane GO:0005765 IBA     lysosomal membrane GO:0005765 IEA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     endosome membrane GO:0010008 IEA     endosome membrane GO:0010008 ISO     endosome membrane GO:0010008 ISS     endomembrane system GO:0012505 IEA     actin cytoskeleton GO:0015629 IEA     actin cytoskeleton GO:0015629 ISO     membrane GO:0016020 ISO     membrane GO:0016020 ISS     Golgi-associated vesicle membrane GO:0030660 IBA     Golgi-associated vesicle membrane GO:0030660 IEA     Golgi-associated vesicle membrane GO:0030660 ISO     Golgi-associated vesicle membrane GO:0030660 ISS     organelle membrane GO:0031090 IEA     lumenal side of endoplasmic reticulum membrane GO:0098553 IBA     lumenal side of endoplasmic reticulum membrane GO:0098553 IEA     lumenal side of endoplasmic reticulum membrane GO:0098553 ISO     lumenal side of endoplasmic reticulum membrane GO:0098553 ISS     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 IBA     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 IEA     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 ISO     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 ISS