Gene description for Src42A
Gene name Src oncogene at 42A
Gene symbol Src42A
Other names/aliases CG14471
CG44128
CG7873
DSrc42A
Dm SRC41
DmHD-29
DmelCG44128
Dmel_CG14471
Dmel_CG7873
Dsrc41
Dsrc42A
Dtk5
HD-29
SK2-4
SRC 42A
SRC42A
Src
Src41
Src42
Src42a
Su(D-raf)1
Su(Raf)1
Su(phl)1
Su1
Tk5
dSrc
dtk-5
dtk5
l(2)k10108
src
src42
src42A
src42a
Species Drosophila melanogaster
 Database cross references - Src42A
ExoCarta ExoCarta_35524
Entrez Gene 35524
UniProt Q9V9J3  
 Src42A identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Src42A
Molecular Function
    non-membrane spanning protein tyrosine kinase activity GO:0004715 ISS
    protein serine/threonine kinase activity GO:0004674 IEA
    protein tyrosine kinase activity GO:0004713 NAS
    ATP binding GO:0005524 IEA
Biological Process
    protein phosphorylation GO:0006468 NAS
    tricarboxylic acid cycle GO:0006099 IDA
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    dorsal closure GO:0007391 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    adherens junction organization GO:0034332 IMP
    open tracheal system development GO:0007424 IMP
    cell migration GO:0016477 IMP
    apoptotic cell clearance GO:0043277 IMP
    cell communication GO:0007154 IDA
    defense response to bacterium GO:0042742 IMP
    negative regulation of synaptic growth at neuromuscular junction GO:0045886 IGI
    dorsal closure, spreading of leading edge cells GO:0007395 IMP
    axon guidance GO:0007411 IMP
    imaginal disc fusion, thorax closure GO:0046529 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IGI
    epithelial cell-cell adhesion GO:0090136 IMP
    salivary gland morphogenesis GO:0007435 IMP
    compound eye development GO:0048749 IMP
    JNK cascade GO:0007254 TAS
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IGI
    intestinal stem cell homeostasis GO:0036335 IMP
    actin filament bundle assembly GO:0051017 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    adherens junction GO:0005912 IDA
 Experiment description of studies that identified Src42A in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Src42A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Src42A is involved
No pathways found





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