Gene description for Slc7a6
Gene name solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Gene symbol Slc7a6
Other names/aliases AI643885
LAT-2
LAT3
Species Mus musculus
 Database cross references - Slc7a6
ExoCarta ExoCarta_330836
Vesiclepedia VP_330836
Entrez Gene 330836
UniProt Q8BGK6  
 Slc7a6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc7a6
Molecular Function
    basic amino acid transmembrane transporter activity GO:0015174 ISO
    L-amino acid transmembrane transporter activity GO:0015179 IBA
    arginine binding GO:0034618 ISO
    arginine binding GO:0034618 ISS
    L-arginine transmembrane transporter activity GO:0061459 ISO
    L-arginine transmembrane transporter activity GO:0061459 ISS
    L-lysine:L-arginine antiporter activity GO:0106439 ISO
    L-lysine:L-arginine antiporter activity GO:0106439 ISS
Biological Process
    amino acid transmembrane transport GO:0003333 IBA
    nitric oxide biosynthetic process GO:0006809 ISO
    nitric oxide biosynthetic process GO:0006809 ISS
    neutral amino acid transport GO:0015804 ISO
    neutral amino acid transport GO:0015804 ISS
    L-leucine transport GO:0015820 IEA
    L-leucine transport GO:0015820 ISO
    ornithine transport GO:0015822 IEA
    ornithine transport GO:0015822 ISO
    glycine betaine transport GO:0031460 IDA
    L-lysine transmembrane transport GO:1903401 IEA
    L-arginine transmembrane transport GO:1903826 ISO
    L-arginine transmembrane transport GO:1903826 ISS
Subcellular Localization
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Slc7a6 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc7a6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg12  
Positive Genetic Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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