Gene description for ANXA6
Gene name annexin A6
Gene symbol ANXA6
Other names/aliases -
Species Bos taurus
 Database cross references - ANXA6
ExoCarta ExoCarta_327685
Entrez Gene 327685
UniProt P79134  
 ANXA6 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ANXA6
Molecular Function
    ligand-gated ion channel activity GO:0015276 IEA
    calcium-dependent protein binding GO:0048306 IPI
    calcium channel activity GO:0005262 IMP
    cholesterol binding GO:0015485 IEA
    chondroitin sulfate binding GO:0035374 IDA
    phosphatidylserine binding GO:0001786 IPI
    protein homodimerization activity GO:0042803 IEA
    identical protein binding GO:0042802 IPI
    GTP binding GO:0005525 IEA
    calcium-dependent phospholipid binding GO:0005544 IDA
    receptor activity GO:0004872 IDA
    enzyme binding GO:0019899 IPI
    calcium ion binding GO:0005509 IEA
    actin filament binding GO:0051015 IPI
    heparin binding GO:0008201 IDA
Biological Process
    calcium ion transmembrane transport GO:0070588 IDA
    calcium ion transport GO:0006816 ISS
    biomineral tissue development GO:0031214 IDA
    regulation of muscle contraction GO:0006937 ISS
    growth plate cartilage chondrocyte differentiation GO:0003418 IDA
    protein homooligomerization GO:0051260 IEA
    calcium ion import GO:0070509 IMP
    negative regulation of sequestering of calcium ion GO:0051283 IDA
Subcellular Localization
    mitochondrial crista GO:0030061 IDA
    chromaffin granule membrane GO:0042584 IDA
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 IEA
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IDA
    cytosol GO:0005829 IDA
    membrane-bounded vesicle GO:0031988 IDA
    perinuclear region of cytoplasm GO:0048471 ISS
    late endosome membrane GO:0031902 IEA
    melanosome GO:0042470 IEA
    stress fiber GO:0001725 IMP
    integral component of membrane GO:0016021 TAS
    focal adhesion GO:0005925 IMP
 Experiment description of studies that identified ANXA6 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ANXA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANXA6 is involved
PathwayEvidenceSource
Muscle contraction IEA Reactome





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