ExoCarta: Gene summary

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Gene description for CACNB2
Gene name	calcium channel, voltage-dependent, beta 2 subunit
Gene symbol	CACNB2
Other names/aliases	-
Species	Bos taurus
Database cross references - CACNB2
ExoCarta	ExoCarta_327667
Vesiclepedia	VP_327667
Entrez Gene	327667
UniProt	Q9MZL5
CACNB2 identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for CACNB2

Molecular Function
	protein binding	GO:0005515	IEA
	high voltage-gated calcium channel activity	GO:0008331	IEA
Biological Process
	chemical synaptic transmission	GO:0007268	IEA
	neuromuscular junction development	GO:0007528	IEA
	calcium ion transmembrane transport	GO:0070588	IEA
	regulation of voltage-gated calcium channel activity	GO:1901385	IEA
Subcellular Localization
	voltage-gated calcium channel complex	GO:0005891	IEA

Experiment description of studies that identified CACNB2 in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for CACNB2

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which CACNB2 is involved

Pathway	Evidence	Source
Cardiac conduction	IEA	Reactome
Integration of energy metabolism	IEA	Reactome
Metabolism	IEA	Reactome
Muscle contraction	IEA	Reactome
Neuronal System	IEA	Reactome
Phase 0 - rapid depolarisation	IEA	Reactome
Phase 2 - plateau phase	IEA	Reactome
Presynaptic depolarization and calcium channel opening	IEA	Reactome
Regulation of insulin secretion	IEA	Reactome
Transmission across Chemical Synapses	IEA	Reactome

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