Gene description for Chd7
Gene name chromodomain helicase DNA binding protein 7
Gene symbol Chd7
Other names/aliases A730019I05Rik
Cycn
Cyn
Dz
Edy
Flo
GENA 47
GENA 60
Gena 52
Lda
Mt
Obt
Todo
WBE1
Whi
metis
Species Mus musculus
 Database cross references - Chd7
ExoCarta ExoCarta_320790
Vesiclepedia VP_320790
Entrez Gene 320790
UniProt A2AJK6  
 Chd7 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Chd7
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA binding GO:0003677 IBA
    chromatin binding GO:0003682 IBA
    DNA clamp loader activity GO:0003689 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IEA
    double-stranded DNA helicase activity GO:0036121 IEA
    histone binding GO:0042393 IBA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent chromatin remodeler activity GO:0140658 IBA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    skeletal system development GO:0001501 IEA
    skeletal system development GO:0001501 ISO
    blood vessel development GO:0001568 IMP
    in utero embryonic development GO:0001701 IMP
    in utero embryonic development GO:0001701 ISO
    blood vessel remodeling GO:0001974 IMP
    heart morphogenesis GO:0003007 IBA
    heart morphogenesis GO:0003007 IMP
    heart morphogenesis GO:0003007 ISO
    ventricular trabecula myocardium morphogenesis GO:0003222 IMP
    right ventricular compact myocardium morphogenesis GO:0003226 IMP
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 IMP
    rRNA processing GO:0006364 IEA
    transcription by RNA polymerase II GO:0006366 IMP
    central nervous system development GO:0007417 IBA
    central nervous system development GO:0007417 ISO
    adult heart development GO:0007512 IMP
    sensory perception of sound GO:0007605 IMP
    locomotory behavior GO:0007626 IMP
    adult walking behavior GO:0007628 IMP
    blood circulation GO:0008015 IMP
    response to bacterium GO:0009617 IEP
    regulation of gene expression GO:0010468 IBA
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 IMP
    cranial nerve development GO:0021545 IBA
    cranial nerve development GO:0021545 ISO
    olfactory nerve development GO:0021553 IMP
    olfactory bulb development GO:0021772 IMP
    T cell differentiation GO:0030217 IEA
    T cell differentiation GO:0030217 ISO
    female genitalia development GO:0030540 IMP
    DNA duplex unwinding GO:0032508 IEA
    embryonic hindlimb morphogenesis GO:0035116 IMP
    aorta development GO:0035904 IMP
    aorta morphogenesis GO:0035909 IMP
    atrioventricular canal development GO:0036302 IMP
    positive regulation of multicellular organism growth GO:0040018 IMP
    olfactory behavior GO:0042048 IMP
    ear morphogenesis GO:0042471 IMP
    inner ear morphogenesis GO:0042472 IBA
    inner ear morphogenesis GO:0042472 IMP
    inner ear morphogenesis GO:0042472 ISO
    chordate embryonic development GO:0043009 IBA
    camera-type eye development GO:0043010 IMP
    nose development GO:0043584 IMP
    nose development GO:0043584 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    semicircular canal morphogenesis GO:0048752 IGI
    tissue remodeling GO:0048771 IMP
    genitalia development GO:0048806 ISO
    artery morphogenesis GO:0048844 IGI
    regulation of neurogenesis GO:0050767 IMP
    cognition GO:0050890 IEA
    cognition GO:0050890 ISO
    roof of mouth development GO:0060021 IMP
    retina development in camera-type eye GO:0060041 IEA
    retina development in camera-type eye GO:0060041 ISO
    regulation of growth hormone secretion GO:0060123 IEA
    regulation of growth hormone secretion GO:0060123 ISO
    limb development GO:0060173 ISO
    face development GO:0060324 IEA
    face development GO:0060324 ISO
    innervation GO:0060384 IMP
    cardiac septum morphogenesis GO:0060411 IMP
    epithelium development GO:0060429 IMP
    secondary palate development GO:0062009 IEA
    secondary palate development GO:0062009 ISO
    chromatin looping GO:0140588 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Chd7 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Chd7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Terf2  
Co-fractionation Mus musculus
2 Elf5  
Affinity Capture-MS Mus musculus
3 Fmr1  
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Thrb  
Affinity Capture-MS Mus musculus
6 Tfe3  
Affinity Capture-MS Mus musculus
7 Brd7  
Co-fractionation Mus musculus
8 Nanog  
Affinity Capture-MS Mus musculus
9 Twist1  
Proximity Label-MS Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Phenotypic Enhancement Mus musculus
View the network image/svg+xml
 Pathways in which Chd7 is involved
No pathways found





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