Gene description for Hist2h2ac
Gene name histone cluster 2, H2ac
Gene symbol Hist2h2ac
Other names/aliases H2a-613b
Species Mus musculus
 Database cross references - Hist2h2ac
ExoCarta ExoCarta_319176
Vesiclepedia VP_319176
Entrez Gene 319176
UniProt Q64523  
 Hist2h2ac identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Hist2h2ac
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IBA
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    heterochromatin formation GO:0031507 IBA
Subcellular Localization
    nucleosome GO:0000786 IBA
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Hist2h2ac in sEVs
1
Experiment ID 33
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hist2h2ac
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Rnf8  
Biochemical Activity Mus musculus
4 Chfr  
Biochemical Activity Mus musculus
5 Eed  
Affinity Capture-MS Mus musculus
6 Scmh1  
Biochemical Activity Mus musculus
7 Ddb1 13194
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hist2h2ac is involved
PathwayEvidenceSource
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance IEA Reactome
Cleavage of the damaged purine IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
Deposition of new CENPA-containing nucleosomes at the centromere IEA Reactome
Depurination IEA Reactome
Deubiquitination IEA Reactome
DNA Damage/Telomere Stress Induced Senescence IEA Reactome
DNA Repair IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HDACs deacetylate histones IEA Reactome
Inhibition of DNA recombination at telomere IEA Reactome
M Phase IEA Reactome
Metabolism of proteins IEA Reactome
Metalloprotease DUBs IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Nucleosome assembly IEA Reactome
Post-translational protein modification IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
RMTs methylate histone arginines IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Telomere Maintenance IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Ub-specific processing proteases IEA Reactome
UCH proteinases IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here