Gene description for Cops5
Gene name COP9 signalosome subunit 5
Gene symbol Cops5
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cops5
ExoCarta ExoCarta_312916
Vesiclepedia VP_312916
Entrez Gene 312916
 Cops5 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cops5
Molecular Function
    metallopeptidase activity GO:0008237 IBA
    metallopeptidase activity GO:0008237 ISO
    deNEDDylase activity GO:0019784 IBA
    enzyme binding GO:0019899 ISO
    macrophage migration inhibitory factor binding GO:0035718 ISO
    metal-dependent deubiquitinase activity GO:0140492 ISO
Biological Process
    protein deneddylation GO:0000338 ISO
    reproductive process GO:0022414 IBA
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    regulation of JNK cascade GO:0046328 ISO
    positive regulation of DNA-binding transcription factor activity GO:0051091 ISO
    regulation of cell cycle GO:0051726 IBA
    regulation of cell cycle GO:0051726 ISO
    regulation of IRE1-mediated unfolded protein response GO:1903894 ISO
    exosomal secretion GO:1990182 ISO
    positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO
Subcellular Localization
    chromatin GO:0000785 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    synaptic vesicle GO:0008021 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Cops5 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cops5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Htr6  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Cops5 is involved
No pathways found





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