Gene description for Cops5
Gene name COP9 signalosome subunit 5
Gene symbol Cops5
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cops5
ExoCarta ExoCarta_312916
Entrez Gene 312916
 Cops5 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cops5
Molecular Function
    metallopeptidase activity GO:0008237 ISO
    ubiquitin-specific protease activity GO:0004843 ISO
Biological Process
    protein deubiquitination GO:0016579 ISO
    protein deneddylation GO:0000338 ISO
    exosomal secretion GO:1990182 ISO
    regulation of cell cycle GO:0051726 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    cullin deneddylation GO:0010388 ISO
    regulation of IRE1-mediated unfolded protein response GO:1903894 ISO
    regulation of JNK cascade GO:0046328 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    synaptic vesicle GO:0008021 ISO
    nucleus GO:0005634 ISO
    COP9 signalosome GO:0008180 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Cops5 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cops5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cops5 is involved
No pathways found





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