Gene description for Pon3
Gene name paraoxonase 3
Gene symbol Pon3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pon3
ExoCarta ExoCarta_312086
Vesiclepedia VP_312086
Entrez Gene 312086
UniProt Q68FP2  
 Pon3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pon3
Molecular Function
    aryldialkylphosphatase activity GO:0004063 IEA
    arylesterase activity GO:0004064 IBA
    arylesterase activity GO:0004064 IDA
    arylesterase activity GO:0004064 IEA
    arylesterase activity GO:0004064 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    metal ion binding GO:0046872 IEA
    dihydrocoumarin hydrolase activity GO:0047856 IDA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 IEA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 ISO
Biological Process
    renal sodium ion transport GO:0003096 IEA
    renal sodium ion transport GO:0003096 ISO
    response to toxic substance GO:0009636 IBA
    phenylacetate catabolic process GO:0010124 IDA
    negative regulation of superoxide anion generation GO:0032929 IEA
    negative regulation of superoxide anion generation GO:0032929 ISO
    coumarin catabolic process GO:0046226 IDA
    carboxylic acid catabolic process GO:0046395 IEA
    carboxylic acid catabolic process GO:0046395 ISO
    establishment of localization in cell GO:0051649 IEA
    establishment of localization in cell GO:0051649 ISO
    lactone catabolic process GO:1901335 IEA
    lactone catabolic process GO:1901335 ISO
    regulation of cellular response to drug GO:2001038 IEA
    regulation of cellular response to drug GO:2001038 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Pon3 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pon3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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