Gene description for Itpa
Gene name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Gene symbol Itpa
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Itpa
ExoCarta ExoCarta_311422
Entrez Gene 311422
UniProt D3ZW55  
 Itpa identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Itpa
Molecular Function
    ITP diphosphatase activity GO:0036220 ISO
    nucleotide binding GO:0000166 IEA
    metal ion binding GO:0046872 IEA
    molecular_function GO:0003674 ND
    dITP diphosphatase activity GO:0035870 ISO
    nucleoside-triphosphate diphosphatase activity GO:0047429 ISO
    XTP diphosphatase activity GO:0036222 ISO
Biological Process
    biological_process GO:0008150 ND
    deoxyribonucleoside triphosphate catabolic process GO:0009204 IEA
    chromosome organization GO:0051276 ISO
    ITP catabolic process GO:0006193 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Itpa in exosomes
1
Experiment ID 98
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Itpa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itpa is involved
PathwayEvidenceSource
Metabolism of nucleotides IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here