Gene description for Glrx3
Gene name glutaredoxin 3
Gene symbol Glrx3
Other names/aliases PICOT
Txnl2
Species Mus musculus
 Database cross references - Glrx3
ExoCarta ExoCarta_30926
Vesiclepedia VP_30926
Entrez Gene 30926
UniProt Q9CQM9  
 Glrx3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Glrx3
Molecular Function
    protein kinase C binding GO:0005080 ISO
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    iron-sulfur cluster binding GO:0051536 IEA
Biological Process
    regulation of the force of heart contraction GO:0002026 IMP
    intracellular iron ion homeostasis GO:0006879 IBA
    intracellular iron ion homeostasis GO:0006879 ISO
    negative regulation of cardiac muscle hypertrophy GO:0010614 IMP
    iron-sulfur cluster assembly GO:0016226 ISO
    [2Fe-2S] cluster assembly GO:0044571 ISO
    [2Fe-2S] cluster assembly GO:0044571 ISS
    cell redox homeostasis GO:0045454 ISO
    protein maturation by iron-sulfur cluster transfer GO:0097428 ISO
    protein maturation by iron-sulfur cluster transfer GO:0097428 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cell cortex GO:0005938 IEA
    Z disc GO:0030018 IDA
    dendrite GO:0030425 ISO
    iron-sulfur cluster assembly complex GO:1990229 ISO
 Experiment description of studies that identified Glrx3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Glrx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Positive Genetic Mus musculus
2 Rcn1  
Co-fractionation Mus musculus
3 Stau1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Glrx3 is involved
No pathways found





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