Gene description for Vcl
Gene name	vinculin
Gene symbol	Vcl
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Vcl
ExoCarta	ExoCarta_305679
Vesiclepedia	VP_305679
Entrez Gene	305679
UniProt	P85972
Vcl identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Vcl

Molecular Function     dystroglycan binding GO:0002162 IEA     dystroglycan binding GO:0002162 ISO     actin binding GO:0003779 ISO     actin binding GO:0003779 ISO     structural molecule activity GO:0005198 IEA     beta-catenin binding GO:0008013 IBA     small GTPase binding GO:0031267 IPI     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     alpha-catenin binding GO:0045294 IBA     alpha-catenin binding GO:0045294 IEA     alpha-catenin binding GO:0045294 ISO     actin filament binding GO:0051015 IEA     molecular adaptor activity GO:0060090 ISO Biological Process     morphogenesis of an epithelium GO:0002009 IEA     morphogenesis of an epithelium GO:0002009 ISO     cell adhesion GO:0007155 IBA     cell adhesion GO:0007155 IEA     cell adhesion GO:0007155 ISO     lamellipodium assembly GO:0030032 IEA     lamellipodium assembly GO:0030032 ISO     regulation of cell migration GO:0030334 IEA     regulation of cell migration GO:0030334 ISO     adherens junction assembly GO:0034333 IEA     adherens junction assembly GO:0034333 ISO     protein localization to cell surface GO:0034394 IEA     protein localization to cell surface GO:0034394 ISO     apical junction assembly GO:0043297 IEA     apical junction assembly GO:0043297 ISO     axon extension GO:0048675 IEA     axon extension GO:0048675 ISO     regulation of focal adhesion assembly GO:0051893 IEA     regulation of focal adhesion assembly GO:0051893 ISO     platelet aggregation GO:0070527 ISO     epithelial cell-cell adhesion GO:0090136 IEA     epithelial cell-cell adhesion GO:0090136 ISO     regulation of establishment of endothelial barrier GO:1903140 IEA     regulation of establishment of endothelial barrier GO:1903140 ISO     regulation of protein localization to adherens junction GO:1904702 IEA     regulation of protein localization to adherens junction GO:1904702 ISO Subcellular Localization     stress fiber GO:0001725 IDA     podosome GO:0002102 IEA     podosome GO:0002102 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoskeleton GO:0005856 IBA     actin filament GO:0005884 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     brush border GO:0005903 ISS     cell-cell junction GO:0005911 ISO     adherens junction GO:0005912 IBA     adherens junction GO:0005912 IEA     adherens junction GO:0005912 ISO     zonula adherens GO:0005915 ISS     fascia adherens GO:0005916 IEA     fascia adherens GO:0005916 ISO     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 IDA     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     intercalated disc GO:0014704 IDA     actin cytoskeleton GO:0015629 ISO     Z disc GO:0030018 IDA     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO     sarcolemma GO:0042383 IDA     sarcolemma GO:0042383 IEA     sarcolemma GO:0042383 ISO     sarcolemma GO:0042383 ISS     cell projection GO:0042995 IEA     costamere GO:0043034 IEA     costamere GO:0043034 ISO     cell-cell contact zone GO:0044291 IBA     cell-cell contact zone GO:0044291 ISO     membrane raft GO:0045121 ISO     podosome ring GO:0061826 IEA     podosome ring GO:0061826 ISO     outer dense plaque of desmosome GO:0090636 ISS     inner dense plaque of desmosome GO:0090637 ISS     terminal web GO:1990357 ISS