Gene description for Atp6ap2
Gene name ATPase, H+ transporting, lysosomal accessory protein 2
Gene symbol Atp6ap2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Atp6ap2
ExoCarta ExoCarta_302526
Entrez Gene 302526
UniProt Q6AXS4  
 Atp6ap2 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Atp6ap2
Molecular Function
    receptor activity GO:0004872 IEA
    molecular_function GO:0003674 ND
    aspartic-type endopeptidase activity GO:0004190 ISO
    enzyme binding GO:0019899 IPI
Biological Process
    eye pigmentation GO:0048069 ISO
    regulation of MAPK cascade GO:0043408 ISO
    head morphogenesis GO:0060323 ISO
    angiotensin maturation GO:0002003 ISO
    positive regulation of transforming growth factor beta1 production GO:0032914 ISO
    biological_process GO:0008150 ND
    positive regulation of Wnt signaling pathway GO:0030177 ISO
    rostrocaudal neural tube patterning GO:0021903 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    external side of plasma membrane GO:0009897 ISO
    cell body GO:0044297 IDA
    cellular_component GO:0005575 ND
    integral component of membrane GO:0016021 IEA
    neuron projection GO:0043005 IDA
 Experiment description of studies that identified Atp6ap2 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Atp6ap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp6ap2 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome





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