Gene description for RGD1566134
Gene name similar to alpha-2u-globulin
Gene symbol RGD1566134
Other names/aliases -
Species Rattus norvegicus
 Database cross references - RGD1566134
ExoCarta ExoCarta_298109
Vesiclepedia VP_298109
Entrez Gene 298109
 RGD1566134 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for RGD1566134
Molecular Function
    insulin receptor activity GO:0005009 ISS
    pheromone binding GO:0005550 IEA
    pheromone binding GO:0005550 ISS
    small molecule binding GO:0036094 IEA
Biological Process
    energy reserve metabolic process GO:0006112 ISS
    mitochondrion organization GO:0007005 ISS
    insulin receptor signaling pathway GO:0008286 IEA
    aerobic respiration GO:0009060 ISS
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of lipid storage GO:0010888 ISS
    positive regulation of glucose metabolic process GO:0010907 ISS
    heat generation GO:0031649 ISS
    glucose homeostasis GO:0042593 ISS
    locomotor rhythm GO:0045475 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
    positive regulation of lipid metabolic process GO:0045834 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    negative regulation of lipid biosynthetic process GO:0051055 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 ISS
    cellular response to lipid GO:0071396 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified RGD1566134 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for RGD1566134
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RGD1566134 is involved
No pathways found





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