Gene description for P2ry2
Gene name purinergic receptor P2Y, G-protein coupled, 2
Gene symbol P2ry2
Other names/aliases P2Y2
Species Rattus norvegicus
 Database cross references - P2ry2
ExoCarta ExoCarta_29597
Vesiclepedia VP_29597
Entrez Gene 29597
UniProt P41232  
 P2ry2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for P2ry2
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    A1 adenosine receptor binding GO:0031686 IBA
    A1 adenosine receptor binding GO:0031686 IPI
    G protein-coupled purinergic nucleotide receptor activity GO:0045028 IEA
    G protein-coupled purinergic nucleotide receptor activity GO:0045028 TAS
    G protein-coupled UTP receptor activity GO:0045030 IBA
    G protein-coupled UTP receptor activity GO:0045030 IDA
Biological Process
    in utero embryonic development GO:0001701 IEP
    microglial cell activation GO:0001774 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of smooth muscle cell migration GO:0014911 IMP
    negative regulation of ossification GO:0030279 IDA
    positive regulation of prostaglandin secretion GO:0032308 IDA
    positive regulation of chemokine production GO:0032722 IDA
    G protein-coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA
    establishment of localization in cell GO:0051649 ISO
    positive regulation of penile erection GO:0060406 IDA
    mucus secretion GO:0070254 ISO
    positive regulation of mucus secretion GO:0070257 IEA
    positive regulation of mucus secretion GO:0070257 ISO
    response to growth factor GO:0070848 IEP
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to interleukin-1 GO:0071347 IEP
    cellular response to purine-containing compound GO:0071415 IEP
    blood vessel diameter maintenance GO:0097746 IDA
    blood vessel diameter maintenance GO:0097746 IEA
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 EXP
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IDA
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IEP
    regulation of synaptic vesicle exocytosis GO:2000300 EXP
    regulation of synaptic vesicle exocytosis GO:2000300 IDA
    regulation of synaptic vesicle exocytosis GO:2000300 IEP
Subcellular Localization
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    presynaptic active zone membrane GO:0048787 IDA
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified P2ry2 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for P2ry2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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