Gene description for Cisd2
Gene name CDGSH iron sulfur domain 2
Gene symbol Cisd2
Other names/aliases RGD1566242
Species Rattus norvegicus
 Database cross references - Cisd2
ExoCarta ExoCarta_295457
Vesiclepedia VP_295457
Entrez Gene 295457
 Cisd2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Cisd2
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    metal ion binding GO:0046872 IEA
    2 iron, 2 sulfur cluster binding GO:0051537 IBA
    2 iron, 2 sulfur cluster binding GO:0051537 ISO
Biological Process
    autophagy of mitochondrion GO:0000422 IBA
    autophagy of mitochondrion GO:0000422 ISO
    biological_process GO:0008150 ND
    regulation of autophagy GO:0010506 ISO
Subcellular Localization
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
    perinuclear endoplasmic reticulum GO:0097038 ISO
 Experiment description of studies that identified Cisd2 in sEVs
1
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cisd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cisd2 is involved
No pathways found





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