Gene description for Rap1a
Gene name	RAP1A, member of RAS oncogene family
Gene symbol	Rap1a
Other names/aliases	RAP-1A rap 1A
Species	Rattus norvegicus
Database cross references - Rap1a
ExoCarta	ExoCarta_295347
Vesiclepedia	VP_295347
Entrez Gene	295347
UniProt	P62836
Rap1a identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Urine	20535238

Gene ontology annotations for Rap1a

Molecular Function     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     G protein activity GO:0003925 IEA     guanyl-nucleotide exchange factor activity GO:0005085 IMP     protein binding GO:0005515 IPI     GTP binding GO:0005525 IBA     GTP binding GO:0005525 IDA     GTP binding GO:0005525 IEA     GDP binding GO:0019003 IBA     small GTPase binding GO:0031267 ISO     protein-containing complex binding GO:0044877 ISO Biological Process     signal transduction GO:0007165 IEA     small GTPase-mediated signal transduction GO:0007264 ISO     nervous system development GO:0007399 IEA     response to carbohydrate GO:0009743 IEP     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of neuron projection development GO:0010976 ISO     synaptic vesicle exocytosis GO:0016079 ISO     microvillus assembly GO:0030033 ISO     Rap protein signal transduction GO:0032486 IBA     Rap protein signal transduction GO:0032486 IEA     Rap protein signal transduction GO:0032486 ISO     Rap protein signal transduction GO:0032486 ISS     negative regulation of collagen biosynthetic process GO:0032966 IMP     nerve growth factor signaling pathway GO:0038180 IDA     positive regulation of GTPase activity GO:0043547 IMP     positive regulation of protein kinase activity GO:0045860 IMP     positive regulation of D-glucose import GO:0046326 IMP     positive regulation of phagocytosis GO:0050766 IMP     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IMP     establishment of endothelial barrier GO:0061028 ISO     establishment of endothelial barrier GO:0061028 ISS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to cAMP GO:0071320 IBA     cellular response to cAMP GO:0071320 IEP     cellular response to cAMP GO:0071320 ISO     cellular response to cAMP GO:0071320 ISS     cellular response to organic cyclic compound GO:0071407 IDA     cellular response to xenobiotic stimulus GO:0071466 IDA     protein localization to plasma membrane GO:0072659 ISO     protein localization to plasma membrane GO:0072659 ISS     response to antineoplastic agent GO:0097327 IDA     liver regeneration GO:0097421 IEP     regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 ISO     regulation of cell junction assembly GO:1901888 ISO     regulation of cell junction assembly GO:1901888 ISS     cellular response to nerve growth factor stimulus GO:1990090 IDA     cellular response to nerve growth factor stimulus GO:1990090 IEP     negative regulation of synaptic vesicle exocytosis GO:2000301 IBA     negative regulation of synaptic vesicle exocytosis GO:2000301 ISO     positive regulation of vasculogenesis GO:2001214 ISO     positive regulation of vasculogenesis GO:2001214 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     early endosome GO:0005769 IDA     late endosome GO:0005770 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     endomembrane system GO:0012505 IEA     membrane GO:0016020 IEA     cell junction GO:0030054 ISO     cell junction GO:0030054 ISS     guanyl-nucleotide exchange factor complex GO:0032045 ISO     neuron projection GO:0043005 ISO     phagocytic vesicle GO:0045335 IDA     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS     anchoring junction GO:0070161 IEA     sperm midpiece GO:0097225 ISO     sperm midpiece GO:0097225 ISS     presynapse GO:0098793 IEA     glutamatergic synapse GO:0098978 ISO