Gene description for GSTM1
Gene name glutathione S-transferase mu 1
Gene symbol GSTM1
Other names/aliases GST1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
GTH4
GTM1
H-B
MU
MU-1
Species Homo sapiens
 Database cross references - GSTM1
ExoCarta ExoCarta_2944
Entrez Gene 2944
HGNC 4632
MIM 138350
UniProt P09488  
 GSTM1 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GSTM1
Molecular Function
    glutathione binding GO:0043295 IDA
    enzyme binding GO:0019899 IPI
    protein homodimerization activity GO:0042803 IPI
    glutathione transferase activity GO:0004364 IDA
Biological Process
    xenobiotic metabolic process GO:0006805 TAS
    xenobiotic catabolic process GO:0042178 IDA
    glutathione metabolic process GO:0006749 IDA
    cellular detoxification of nitrogen compound GO:0070458 IDA
    glutathione derivative biosynthetic process GO:1901687 TAS
    nitrobenzene metabolic process GO:0018916 IDA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified GSTM1 in exosomes
1
Experiment ID 189
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GSTM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTM1 2944
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 GSTM2 2946
Invitro Homo sapiens
3 MAP3K5  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GSTM1 is involved
PathwayEvidenceSource
Glutathione conjugation TAS Reactome





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