Gene description for Atp8b1
Gene name ATPase, aminophospholipid transporter, class I, type 8B, member 1
Gene symbol Atp8b1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Atp8b1
ExoCarta ExoCarta_291555
Entrez Gene 291555
 Atp8b1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Atp8b1
Molecular Function
    cardiolipin binding GO:1901612 ISO
    magnesium ion binding GO:0000287 IEA
    phospholipid-translocating ATPase activity GO:0004012 IBA
    ATP binding GO:0005524 IEA
    molecular_function GO:0003674 ND
    lipid transporter activity GO:0005319 ISO
Biological Process
    Golgi organization GO:0007030 IBA
    phospholipid translocation GO:0045332 ISO
    inner ear receptor cell development GO:0060119 ISO
    biological_process GO:0008150 ND
    regulation of microvillus assembly GO:0032534 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    vestibulocochlear nerve formation GO:0021650 ISO
    lipid transport GO:0006869 ISO
    bile acid metabolic process GO:0008206 ISO
    sensory perception of sound GO:0007605 ISO
    drug transmembrane transport GO:0006855 ISO
Subcellular Localization
    membrane GO:0016020 IDA
    stereocilium GO:0032420 ISO
    apical plasma membrane GO:0016324 ISO
    endoplasmic reticulum GO:0005783 ISO
    brush border membrane GO:0031526 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 ISO
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Atp8b1 in exosomes
1
Experiment ID 96
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Atp8b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp8b1 is involved
No pathways found





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