Gene description for Hsd17b11
Gene name hydroxysteroid (17-beta) dehydrogenase 11
Gene symbol Hsd17b11
Other names/aliases Dhrs8
Species Rattus norvegicus
 Database cross references - Hsd17b11
ExoCarta ExoCarta_289456
Vesiclepedia VP_289456
Entrez Gene 289456
UniProt Q6AYS8  
 Hsd17b11 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hsd17b11
Molecular Function
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 ISO
    steroid dehydrogenase activity GO:0016229 IBA
    steroid dehydrogenase activity GO:0016229 ISO
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IBA
Biological Process
    steroid biosynthetic process GO:0006694 IEA
    androgen catabolic process GO:0006710 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IEA
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 ISO
 Experiment description of studies that identified Hsd17b11 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hsd17b11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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