Gene description for PSEN1
Gene name	presenilin 1
Gene symbol	PSEN1
Other names/aliases	-
Species	Bos taurus
Database cross references - PSEN1
ExoCarta	ExoCarta_282705
Entrez Gene	282705
UniProt	Q9XT97
PSEN1 identified in exosomes derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for PSEN1

Molecular Function     PDZ domain binding GO:0030165 IEA     beta-catenin binding GO:0008013 IBA     aspartic-type endopeptidase activity GO:0004190 IEA     calcium channel activity GO:0005262 IEA     endopeptidase activity GO:0004175 IBA     cadherin binding GO:0045296 IBA Biological Process     Notch receptor processing GO:0007220 IBA     regulation of protein binding GO:0043393 IEA     mitochondrial transport GO:0006839 IEA     positive regulation of catalytic activity GO:0043085 ISS     Cajal-Retzius cell differentiation GO:0021870 IEA     negative regulation of epidermal growth factor-activated receptor activity GO:0007175 IEA     thymus development GO:0048538 IEA     somitogenesis GO:0001756 IEA     amyloid precursor protein catabolic process GO:0042987 IBA     negative regulation of apoptotic process GO:0043066 IBA     protein processing GO:0016485 ISS     neuron development GO:0048666 IEA     cellular response to DNA damage stimulus GO:0006974 IEA     negative regulation of axonogenesis GO:0050771 IEA     blood vessel development GO:0001568 IEA     autophagosome assembly GO:0000045 IEA     membrane protein ectodomain proteolysis GO:0006509 ISS     dorsal/ventral neural tube patterning GO:0021904 IEA     intracellular signal transduction GO:0035556 IEA     L-glutamate transport GO:0015813 IEA     response to oxidative stress GO:0006979 IEA     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA     negative regulation of apoptotic signaling pathway GO:2001234 IEA     memory GO:0007613 IEA     regulation of resting membrane potential GO:0060075 IEA     positive regulation of apoptotic process GO:0043065 IEA     neuron apoptotic process GO:0051402 IEA     regulation of synaptic transmission, glutamatergic GO:0051966 IEA     positive regulation of MAP kinase activity GO:0043406 IEA     canonical Wnt signaling pathway GO:0060070 IBA     beta-amyloid formation GO:0034205 IEA     choline transport GO:0015871 IEA     brain morphogenesis GO:0048854 IEA     neuron migration GO:0001764 IEA     negative regulation of ubiquitin-protein transferase activity GO:0051444 IEA     T cell receptor signaling pathway GO:0050852 IEA     negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000059 IEA     myeloid dendritic cell differentiation GO:0043011 IEA     activation of MAPKK activity GO:0000186 IEA     synaptic vesicle targeting GO:0016080 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IBA     T cell activation involved in immune response GO:0002286 IEA     Notch signaling pathway GO:0007219 IEA     positive regulation of receptor recycling GO:0001921 IEA     skeletal system morphogenesis GO:0048705 IEA     protein glycosylation GO:0006486 IEA     cerebral cortex cell migration GO:0021795 IEA     calcium ion transmembrane transport GO:0070588 IEA     embryonic limb morphogenesis GO:0030326 IEA     epithelial cell proliferation GO:0050673 IEA     positive regulation of coagulation GO:0050820 IEA     heart looping GO:0001947 IEA     post-embryonic development GO:0009791 IEA     skin morphogenesis GO:0043589 IEA     protein transport GO:0015031 IEA     calcium ion transport GO:0006816 IBA     beta-amyloid metabolic process GO:0050435 IBA     cell fate specification GO:0001708 IEA     hematopoietic progenitor cell differentiation GO:0002244 IEA     regulation of synaptic plasticity GO:0048167 IEA Subcellular Localization     Golgi apparatus GO:0005794 ISS     lysosomal membrane GO:0005765 IBA     integral component of plasma membrane GO:0005887 ISS     perinuclear region of cytoplasm GO:0048471 IBA     nucleus GO:0005634 IBA     plasma membrane GO:0005886 ISS     growth cone GO:0030426 IBA     neuromuscular junction GO:0031594 IBA     cytoplasmic vesicle GO:0031410 IEA     centrosome GO:0005813 IEA     smooth endoplasmic reticulum GO:0005790 IEA     Z disc GO:0030018 IBA     kinetochore GO:0000776 IEA     cell surface GO:0009986 IBA     mitochondrion GO:0005739 ISS     axon GO:0030424 IBA     dendritic shaft GO:0043198 IBA     aggresome GO:0016235 ISS     membrane raft GO:0045121 IBA     Golgi membrane GO:0000139 IEA     cell cortex GO:0005938 IBA     rough endoplasmic reticulum GO:0005791 IEA     endoplasmic reticulum GO:0005783 ISS     neuronal cell body GO:0043025 IBA     apical plasma membrane GO:0016324 IBA     nuclear outer membrane GO:0005640 IEA     mitochondrial inner membrane GO:0005743 IBA     endoplasmic reticulum membrane GO:0005789 IEA     gamma-secretase complex GO:0070765 IEA     ciliary rootlet GO:0035253 IBA