Gene description for PPM1A
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene symbol PPM1A
Other names/aliases PP2C-alpha
Species Bos taurus
 Database cross references - PPM1A
ExoCarta ExoCarta_281994
Vesiclepedia VP_281994
Entrez Gene 281994
UniProt O62829  
 PPM1A identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPM1A
Molecular Function
    magnesium ion binding GO:0000287 IEA
    protein serine/threonine phosphatase activity GO:0004722 IEA
    manganese ion binding GO:0030145 IEA
Biological Process
    protein dephosphorylation GO:0006470 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified PPM1A in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPM1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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