Gene description for GNAS
Gene name GNAS complex locus
Gene symbol GNAS
Other names/aliases GNAS1
Species Bos taurus
 Database cross references - GNAS
ExoCarta ExoCarta_281793
Entrez Gene 281793
UniProt P04896   O18979  
 GNAS identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GNAS
Molecular Function
    signal transducer activity GO:0004871 ISS
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
    metal ion binding GO:0046872 IEA
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
Biological Process
    positive regulation of osteoclast differentiation GO:0045672 IEA
    positive regulation of GTPase activity GO:0043547 ISS
    post-embryonic body morphogenesis GO:0040032 IEA
    cognition GO:0050890 IEA
    positive regulation of cAMP-mediated signaling GO:0043950 ISS
    negative regulation of multicellular organism growth GO:0040015 ISS
    platelet aggregation GO:0070527 IEA
    DNA methylation GO:0006306 IEA
    response to drug GO:0042493 IEA
    embryonic cranial skeleton morphogenesis GO:0048701 IEA
    cartilage development GO:0051216 IEA
    energy reserve metabolic process GO:0006112 IEA
    multicellular organism growth GO:0035264 IEA
    endochondral ossification GO:0001958 IEA
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA
    embryonic hindlimb morphogenesis GO:0035116 IEA
    genetic imprinting GO:0071514 IEA
    hair follicle placode formation GO:0060789 IEA
    positive regulation of cAMP biosynthetic process GO:0030819 ISS
    adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 ISS
    tissue homeostasis GO:0001894 IEA
    positive regulation of osteoblast differentiation GO:0045669 IEA
Subcellular Localization
    dendrite GO:0030425 IEA
    extracellular region GO:0005576 IEA
    transport vesicle GO:0030133 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified GNAS in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNAS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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