Gene description for GNA11
Gene name guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Gene symbol GNA11
Other names/aliases -
Species Bos taurus
 Database cross references - GNA11
ExoCarta ExoCarta_281788
Vesiclepedia VP_281788
Entrez Gene 281788
UniProt P38409  
 GNA11 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GNA11
Molecular Function
    G protein-coupled receptor binding GO:0001664 IEA
    GTPase activity GO:0003924 IEA
    guanyl nucleotide binding GO:0019001 IEA
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
Biological Process
    action potential GO:0001508 IEA
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IEA
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IEA
Subcellular Localization
    heterotrimeric G-protein complex GO:0005834 IEA
 Experiment description of studies that identified GNA11 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNA11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GNA11 is involved
PathwayEvidenceSource
Acetylcholine regulates insulin secretion IEA Reactome
ADP signalling through P2Y purinoceptor 1 IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Chaperonin-mediated protein folding IEA Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding IEA Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion IEA Reactome
Free fatty acids regulate insulin secretion IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome
G-protein activation IEA Reactome
G-protein mediated events IEA Reactome
GPCR downstream signalling IEA Reactome
Hemostasis IEA Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Integration of energy metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Opioid Signalling IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
PLC beta mediated events IEA Reactome
Protein folding IEA Reactome
Regulation of insulin secretion IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
Signal amplification IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Thrombin signalling through proteinase activated receptors (PARs) IEA Reactome
Thromboxane signalling through TP receptor IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here