Gene description for B2M
Gene name beta-2-microglobulin
Gene symbol B2M
Other names/aliases -
Species Bos taurus
 Database cross references - B2M
ExoCarta ExoCarta_280729
Vesiclepedia VP_280729
Entrez Gene 280729
UniProt P01888  
 B2M identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for B2M
Molecular Function
    MHC class II protein complex binding GO:0023026 IEA
Biological Process
    immunoglobulin production involved in immunoglobulin-mediated immune response GO:0002381 IEA
    peptide antigen assembly with MHC class II protein complex GO:0002503 IEA
    immune response GO:0006955 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA
    positive regulation of T cell activation GO:0050870 IEA
Subcellular Localization
    MHC class I protein complex GO:0042612 IEA
    MHC class II protein complex GO:0042613 IEA
 Experiment description of studies that identified B2M in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for B2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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