Gene description for Eif2ak1
Gene name	eukaryotic translation initiation factor 2 alpha kinase 1
Gene symbol	Eif2ak1
Other names/aliases	Hri
Species	Rattus norvegicus
Database cross references - Eif2ak1
ExoCarta	ExoCarta_27137
Vesiclepedia	VP_27137
Entrez Gene	27137
UniProt	Q63185
Eif2ak1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Eif2ak1

Molecular Function     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 IEA     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IBA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IDA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 ISO     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 ISS     ribosomal protein S6 kinase activity GO:0004711 IEA     ATP binding GO:0005524 IEA     heme binding GO:0020037 IEA     heme binding GO:0020037 ISO     heme binding GO:0020037 ISS     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     acute inflammatory response GO:0002526 IEA     acute inflammatory response GO:0002526 ISO     chromatin remodeling GO:0006338 IEA     regulation of translation GO:0006417 IEA     regulation of translation GO:0006417 ISO     regulation of translational initiation GO:0006446 IBA     phagocytosis GO:0006909 IEA     phagocytosis GO:0006909 ISO     response to stress GO:0006950 IEA     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of cell population proliferation GO:0008285 ISO     negative regulation of cell population proliferation GO:0008285 ISS     regulation of eIF2 alpha phosphorylation by heme GO:0010999 ISO     negative regulation of translation GO:0017148 IEA     regulation of metabolic process GO:0019222 IEA     macrophage differentiation GO:0030225 IEA     macrophage differentiation GO:0030225 ISO     protoporphyrinogen IX metabolic process GO:0046501 IEA     protoporphyrinogen IX metabolic process GO:0046501 ISO     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 ISS     regulation of hemoglobin biosynthetic process GO:0046984 ISO     negative regulation of hemoglobin biosynthetic process GO:0046986 IEA     negative regulation of hemoglobin biosynthetic process GO:0046986 ISO     negative regulation of hemoglobin biosynthetic process GO:0046986 ISS     establishment of localization in cell GO:0051649 IEA     establishment of localization in cell GO:0051649 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 IEA     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     protein localization to mitochondrion GO:0070585 IEA     protein localization to mitochondrion GO:0070585 ISO     integrated stress response signaling GO:0140467 ISO     integrated stress response signaling GO:0140467 ISS     HRI-mediated signaling GO:0140468 IEA     HRI-mediated signaling GO:0140468 ISO     HRI-mediated signaling GO:0140468 ISS     positive regulation of mitophagy GO:1901526 IEA     positive regulation of mitophagy GO:1901526 ISO     positive regulation of mitophagy GO:1901526 ISS     response to iron ion starvation GO:1990641 IEA     response to iron ion starvation GO:1990641 ISO     response to iron ion starvation GO:1990641 ISS Subcellular Localization     nucleus GO:0005634 IBA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO