Gene description for Cadps
Gene name Ca2+-dependent secretion activator
Gene symbol Cadps
Other names/aliases AU067781
CAPS
CAPS1
mKIAA1121
Species Mus musculus
 Database cross references - Cadps
ExoCarta ExoCarta_27062
Vesiclepedia VP_27062
Entrez Gene 27062
UniProt Q80TJ1  
 Cadps identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cadps
Molecular Function
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    lipid binding GO:0008289 IEA
    protein kinase binding GO:0019901 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    exocytosis GO:0006887 IMP
    protein transport GO:0015031 IEA
    vesicle organization GO:0016050 IMP
    synaptic vesicle priming GO:0016082 IDA
    synaptic vesicle priming GO:0016082 IGI
    synaptic vesicle priming GO:0016082 IMP
    positive regulation of exocytosis GO:0045921 IBA
    positive regulation of exocytosis GO:0045921 ISO
    positive regulation of calcium ion-dependent exocytosis GO:0045956 ISO
    catecholamine secretion GO:0050432 IMP
    establishment of localization in cell GO:0051649 IMP
    presynaptic dense core vesicle exocytosis GO:0099525 IDA
    presynaptic dense core vesicle exocytosis GO:0099525 IMP
Subcellular Localization
    dense core granule GO:0031045 ISO
    cytoplasmic vesicle GO:0031410 IDA
    extrinsic component of neuronal dense core vesicle membrane GO:0098674 ISO
    presynapse GO:0098793 IEA
    presynapse GO:0098793 ISO
    glutamatergic synapse GO:0098978 IBA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
    neuronal dense core vesicle membrane GO:0099012 IEA
 Experiment description of studies that identified Cadps in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cadps
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A230050P20Rik  
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Cadps is involved
No pathways found





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