Gene description for Ak3
Gene name adenylate kinase 3
Gene symbol Ak3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ak3
ExoCarta ExoCarta_26956
Vesiclepedia VP_26956
Entrez Gene 26956
UniProt P29411  
 Ak3 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Ak3
Molecular Function
    adenylate kinase activity GO:0004017 IDA
    adenylate kinase activity GO:0004017 IEA
    adenylate kinase activity GO:0004017 ISO
    nucleoside diphosphate kinase activity GO:0004550 IEA
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
    nucleoside triphosphate adenylate kinase activity GO:0046899 IBA
    nucleoside triphosphate adenylate kinase activity GO:0046899 IEA
    nucleoside triphosphate adenylate kinase activity GO:0046899 ISO
Biological Process
    liver development GO:0001889 IEP
    ADP biosynthetic process GO:0006172 IDA
    ADP biosynthetic process GO:0006172 IEA
    AMP phosphorylation GO:0006756 IDA
    muscle organ development GO:0007517 IEP
    nucleoside triphosphate biosynthetic process GO:0009142 IBA
    cerebellum development GO:0021549 IEP
    olfactory bulb development GO:0021772 IEP
    response to starvation GO:0042594 IEP
    AMP metabolic process GO:0046033 IBA
    AMP metabolic process GO:0046033 IEA
    AMP metabolic process GO:0046033 ISO
    GTP metabolic process GO:0046039 IEA
    GTP metabolic process GO:0046039 ISO
    ITP metabolic process GO:0046041 IEA
    ITP metabolic process GO:0046041 ISO
    UTP metabolic process GO:0046051 IEA
    UTP metabolic process GO:0046051 ISO
    dATP metabolic process GO:0046060 IDA
    nucleoside monophosphate phosphorylation GO:0046940 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial matrix GO:0005759 ISO
 Experiment description of studies that identified Ak3 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Ak3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ak3 is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production IEA Reactome
Hemostasis IEA Reactome





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