Gene description for Ahcy
Gene name S-adenosylhomocysteine hydrolase
Gene symbol Ahcy
Other names/aliases AA987153
AL024110
CuBP
SAHH
Species Mus musculus
 Database cross references - Ahcy
ExoCarta ExoCarta_269378
Entrez Gene 269378
UniProt P50247  
 Ahcy identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Ahcy
Molecular Function
    identical protein binding GO:0042802 ISO
    adenyl nucleotide binding GO:0030554 ISO
    protein self-association GO:0043621 IPI
    copper ion binding GO:0005507 IDA
    NAD binding GO:0051287 ISO
    adenosylhomocysteinase activity GO:0004013 ISO
Biological Process
    S-adenosylhomocysteine catabolic process GO:0019510 ISO
    chronic inflammatory response to antigenic stimulus GO:0002439 ISO
    homocysteine biosynthetic process GO:0071268 ISO
    response to nutrient GO:0007584 ISO
    circadian sleep/wake cycle GO:0042745 ISO
    S-adenosylmethionine cycle GO:0033353 IBA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    neuron projection GO:0043005 ISO
 Experiment description of studies that identified Ahcy in exosomes
1
Experiment ID 39
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|HSC70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Ahcy
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ahcy is involved
PathwayEvidenceSource
Methylation IEA Reactome
Sulfur amino acid metabolism IEA Reactome





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