Gene description for Nlrc3
Gene name NLR family, CARD domain containing 3
Gene symbol Nlrc3
Other names/aliases CLR16.2
D230007K08Rik
mFLJ00348
Species Mus musculus
 Database cross references - Nlrc3
ExoCarta ExoCarta_268857
Entrez Gene 268857
UniProt Q5DU56  
 Nlrc3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nlrc3
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    nucleotide binding GO:0000166 IEA
Biological Process
    regulation of protein ubiquitination GO:0031396 IMP
    T cell activation GO:0042110 ISS
    I-kappaB kinase/NF-kappaB signaling GO:0007249 ISS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISO
    response to lipopolysaccharide GO:0032496 IMP
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    negative regulation of interleukin-6 production GO:0032715 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Nlrc3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nlrc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nlrc3 is involved
No pathways found





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