Gene description for Slc7a11
Gene name	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Gene symbol	Slc7a11
Other names/aliases	9930009M05Rik AI451155 sut xCT
Species	Mus musculus
Database cross references - Slc7a11
ExoCarta	ExoCarta_26570
Vesiclepedia	VP_26570
Entrez Gene	26570
UniProt	Q9WTR6
Slc7a11 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Slc7a11

Molecular Function     L-amino acid transmembrane transporter activity GO:0015179 IBA     cystine:glutamate antiporter activity GO:0015327 ISO     cystine:glutamate antiporter activity GO:0015327 ISS     L-kynurenine transmembrane transporter activity GO:0140926 ISO     L-kynurenine transmembrane transporter activity GO:0140926 ISS Biological Process     amino acid transmembrane transport GO:0003333 IBA     glutathione metabolic process GO:0006749 IMP     brain development GO:0007420 IMP     visual learning GO:0008542 IMP     response to toxic substance GO:0009636 IEA     response to toxic substance GO:0009636 ISO     response to organic cyclic compound GO:0014070 IMP     L-cystine transport GO:0015811 IMP     L-cystine transport GO:0015811 ISO     L-cystine transport GO:0015811 ISS     L-glutamate transmembrane transport GO:0015813 ISO     L-glutamate transmembrane transport GO:0015813 ISS     ventricular system development GO:0021591 IMP     striatum development GO:0021756 IMP     adult behavior GO:0030534 IDA     regulation of neutrophil apoptotic process GO:0033029 IMP     cellular response to stress GO:0033554 IDA     cellular response to oxidative stress GO:0034599 IDA     cellular response to oxidative stress GO:0034599 IMP     glutathione transmembrane transport GO:0034775 IDA     response to nicotine GO:0035094 IEA     regulation of cell population proliferation GO:0042127 IMP     regulation of melanin biosynthetic process GO:0048021 IMP     lung alveolus development GO:0048286 IMP     modulation of chemical synaptic transmission GO:0050804 IMP     regulation of synapse organization GO:0050807 IMP     regulation of protein transport GO:0051223 IMP     response to redox state GO:0051775 IMP     limb development GO:0060173 IMP     lens fiber cell differentiation GO:0070306 IEA     platelet aggregation GO:0070527 IMP     intracellular glutamate homeostasis GO:0090461 IGI     intracellular glutamate homeostasis GO:0090461 IMP     L-glutamate import across plasma membrane GO:0098712 IMP     negative regulation of ferroptosis GO:0110076 ISO     negative regulation of ferroptosis GO:0110076 ISS     dipeptide import across plasma membrane GO:0140206 IMP     L-kynurenine transmembrane transport GO:0140924 ISO     L-kynurenine transmembrane transport GO:0140924 ISS     regulation of cellular response to oxidative stress GO:1900407 IMP     regulation of cysteine metabolic process GO:1901494 IMP     regulation of glutathione biosynthetic process GO:1903786 IMP     regulation of AMPA glutamate receptor clustering GO:1904717 IMP     regulation of glutamate metabolic process GO:2000211 IMP Subcellular Localization     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     membrane GO:0016020 IDA     brush border membrane GO:0031526 IDA     microvillus membrane GO:0031528 IEA     apical part of cell GO:0045177 IDA     astrocyte projection GO:0097449 IDA