Gene description for Ceacam1
Gene name carcinoembryonic antigen-related cell adhesion molecule 1
Gene symbol Ceacam1
Other names/aliases Bgp
Bgp1
C-CAM
CD66a
Cc1
Cea-1
Cea-7
Cea1
Cea7
Hv-2
Hv2
MHVR
MHVR1
Mhv-1
bb-1
mCEA1
mmCGM1
mmCGM1a
mmCGM2
Species Mus musculus
 Database cross references - Ceacam1
ExoCarta ExoCarta_26365
Vesiclepedia VP_26365
Entrez Gene 26365
UniProt P31809  
 Ceacam1 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Ceacam1
Molecular Function
    virus receptor activity GO:0001618 IEA
    actin binding GO:0003779 ISO
    granulocyte colony-stimulating factor receptor binding GO:0005130 IPI
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 ISO
    calmodulin binding GO:0005516 ISS
    bile acid transmembrane transporter activity GO:0015125 ISO
    bile acid transmembrane transporter activity GO:0015125 ISS
    kinase binding GO:0019900 ISO
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 ISO
    filamin binding GO:0031005 ISO
    GPI anchor binding GO:0034235 ISO
    Toll-like receptor binding GO:0035325 IPI
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    protein-containing complex binding GO:0044877 ISO
    protein heterodimerization activity GO:0046982 ISO
    protein dimerization activity GO:0046983 ISO
    protein dimerization activity GO:0046983 ISS
    protein tyrosine kinase binding GO:1990782 IBA
    protein tyrosine kinase binding GO:1990782 IPI
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    regulation of cell growth GO:0001558 ISO
    regulation of cell growth GO:0001558 ISS
    blood vessel development GO:0001568 IMP
    negative regulation of cytokine production GO:0001818 IMP
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISS
    regulation of immune system process GO:0002682 IBA
    negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 IMP
    negative regulation of protein kinase activity GO:0006469 IMP
    cell adhesion GO:0007155 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISO
    signal transduction GO:0007165 IBA
    regulation of endothelial cell migration GO:0010594 IDA
    bile acid and bile salt transport GO:0015721 ISO
    bile acid and bile salt transport GO:0015721 ISS
    negative regulation of granulocyte differentiation GO:0030853 IMP
    negative regulation of interleukin-1 production GO:0032692 IMP
    cellular response to insulin stimulus GO:0032869 ISO
    cellular response to insulin stimulus GO:0032869 ISS
    common myeloid progenitor cell proliferation GO:0035726 IMP
    insulin receptor internalization GO:0038016 ISO
    insulin receptor internalization GO:0038016 ISS
    granulocyte colony-stimulating factor signaling pathway GO:0038158 IMP
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IMP
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 ISO
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 ISS
    negative regulation of T cell proliferation GO:0042130 IMP
    negative regulation of vascular permeability GO:0043116 IMP
    negative regulation of cytotoxic T cell degranulation GO:0043318 ISS
    positive regulation of MAP kinase activity GO:0043406 ISO
    wound healing, spreading of cells GO:0044319 ISS
    cell-cell junction organization GO:0045216 IMP
    regulation of endothelial cell differentiation GO:0045601 IDA
    negative regulation of osteoclast differentiation GO:0045671 IMP
    negative regulation of fatty acid biosynthetic process GO:0045717 ISO
    negative regulation of fatty acid biosynthetic process GO:0045717 ISS
    negative regulation of bone resorption GO:0045779 IMP
    symbiont entry into host cell GO:0046718 IEA
    negative regulation of T cell receptor signaling pathway GO:0050860 ISS
    negative regulation of lipid biosynthetic process GO:0051055 IMP
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 ISO
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 ISS
    regulation of blood vessel remodeling GO:0060312 IMP
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 ISS
    negative regulation of platelet aggregation GO:0090331 IMP
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 ISO
    insulin catabolic process GO:1901143 IMP
    insulin catabolic process GO:1901143 ISO
    insulin catabolic process GO:1901143 ISS
    regulation of homophilic cell adhesion GO:1903385 ISO
    regulation of homophilic cell adhesion GO:1903385 ISS
    positive regulation of homophilic cell adhesion GO:1903387 ISO
    regulation of sprouting angiogenesis GO:1903670 IMP
    negative regulation of hepatocyte proliferation GO:2000346 IMP
    negative regulation of hepatocyte proliferation GO:2000346 ISO
    negative regulation of hepatocyte proliferation GO:2000346 ISS
    positive regulation of vasculogenesis GO:2001214 IMP
Subcellular Localization
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    cell-cell junction GO:0005911 ISS
    adherens junction GO:0005912 ISO
    adherens junction GO:0005912 ISS
    external side of plasma membrane GO:0009897 IDA
    basal plasma membrane GO:0009925 ISO
    basal plasma membrane GO:0009925 ISS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    lateral plasma membrane GO:0016328 ISO
    lateral plasma membrane GO:0016328 ISS
    cell junction GO:0030054 ISO
    cell junction GO:0030054 ISS
    transport vesicle GO:0030133 IEA
    microvillus membrane GO:0031528 IEA
    T cell receptor complex GO:0042101 ISO
    T cell receptor complex GO:0042101 ISS
    ciliary membrane GO:0060170 IDA
    transforming growth factor beta ligand-receptor complex GO:0070021 ISO
 Experiment description of studies that identified Ceacam1 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Ceacam1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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