Gene description for Adgre5
Gene name adhesion G protein-coupled receptor E5
Gene symbol Adgre5
Other names/aliases AA409984
Cd97
TM7LN1
Species Mus musculus
 Database cross references - Adgre5
ExoCarta ExoCarta_26364
Entrez Gene 26364
UniProt Q9Z0M6  
 Adgre5 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Adgre5
Molecular Function
    transmembrane signaling receptor activity GO:0004888 TAS
    signal transducer activity GO:0004871 IEA
    G-protein coupled receptor activity GO:0004930 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IEA
    signal transduction GO:0007165 TAS
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    cell surface receptor signaling pathway GO:0007166 IEA
    positive regulation of synapse assembly GO:0051965 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
    focal adhesion GO:0005925 ISO
    integral component of membrane GO:0016021 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Adgre5 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Adgre5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adgre5 is involved
PathwayEvidenceSource
Class B/2 (Secretin family receptors) IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here