Gene description for Plekhg3
Gene name pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Gene symbol Plekhg3
Other names/aliases BC030417
Species Mus musculus
 Database cross references - Plekhg3
ExoCarta ExoCarta_263406
Entrez Gene 263406
UniProt Q4VAC9  
 Plekhg3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Plekhg3
Molecular Function
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    molecular_function GO:0003674 ND
Biological Process
    regulation of Rho protein signal transduction GO:0035023 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Plekhg3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Plekhg3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plekhg3 is involved
No pathways found





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