Gene description for Adgrg1
Gene name adhesion G protein-coupled receptor G1
Gene symbol Adgrg1
Other names/aliases Gpr56
Species Rattus norvegicus
 Database cross references - Adgrg1
ExoCarta ExoCarta_260326
Vesiclepedia VP_260326
Entrez Gene 260326
 Adgrg1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Adgrg1
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 IEA
    G protein-coupled receptor activity GO:0004930 ISO
    G protein-coupled receptor activity GO:0004930 ISS
    collagen binding GO:0005518 IEA
    collagen binding GO:0005518 ISO
    collagen binding GO:0005518 ISS
    heparin binding GO:0008201 IBA
    heparin binding GO:0008201 IEA
    heparin binding GO:0008201 ISO
    heparin binding GO:0008201 ISS
    extracellular matrix binding GO:0050840 IEA
    extracellular matrix binding GO:0050840 ISO
    extracellular matrix binding GO:0050840 ISS
Biological Process
    angiogenesis GO:0001525 IEA
    angiogenesis GO:0001525 ISO
    angiogenesis GO:0001525 ISS
    cell adhesion GO:0007155 IEA
    cell adhesion GO:0007155 ISO
    cell adhesion GO:0007155 ISS
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISO
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISS
    Rho protein signal transduction GO:0007266 IEA
    Rho protein signal transduction GO:0007266 ISO
    Rho protein signal transduction GO:0007266 ISS
    nervous system development GO:0007399 IEA
    brain development GO:0007420 ISO
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    negative regulation of cell population proliferation GO:0008285 ISS
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    cerebral cortex regionalization GO:0021796 IEA
    cerebral cortex regionalization GO:0021796 ISO
    cerebral cortex radial glia-guided migration GO:0021801 ISO
    cerebral cortex radial glia-guided migration GO:0021801 ISS
    layer formation in cerebral cortex GO:0021819 IEA
    layer formation in cerebral cortex GO:0021819 ISO
    layer formation in cerebral cortex GO:0021819 ISS
    cell differentiation GO:0030154 IEA
    positive regulation of Rho protein signal transduction GO:0035025 IEA
    positive regulation of Rho protein signal transduction GO:0035025 ISO
    positive regulation of Rho protein signal transduction GO:0035025 ISS
    positive regulation of cell adhesion GO:0045785 IEA
    positive regulation of cell adhesion GO:0045785 ISO
    positive regulation of cell adhesion GO:0045785 ISS
    neural precursor cell proliferation GO:0061351 IEA
    neural precursor cell proliferation GO:0061351 ISO
    hematopoietic stem cell homeostasis GO:0061484 IEA
    hematopoietic stem cell homeostasis GO:0061484 ISO
    seminiferous tubule development GO:0072520 IEA
    seminiferous tubule development GO:0072520 ISO
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 IEA
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISO
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISS
    positive regulation of neural precursor cell proliferation GO:2000179 IEA
    positive regulation of neural precursor cell proliferation GO:2000179 ISO
    negative regulation of neuron migration GO:2001223 IEA
    negative regulation of neuron migration GO:2001223 ISO
    negative regulation of neuron migration GO:2001223 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    membrane raft GO:0045121 IEA
    glial limiting end-foot GO:0097451 IEA
    glial limiting end-foot GO:0097451 ISO
    glial limiting end-foot GO:0097451 ISS
 Experiment description of studies that identified Adgrg1 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Adgrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adgrg1 is involved
No pathways found





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