Gene description for Ide
Gene name	insulin degrading enzyme
Gene symbol	Ide
Other names/aliases	INSDEGM
Species	Rattus norvegicus
Database cross references - Ide
ExoCarta	ExoCarta_25700
Vesiclepedia	VP_25700
Entrez Gene	25700
UniProt	P35559
Ide identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Ide

Molecular Function     amyloid-beta binding GO:0001540 IPI     endopeptidase activity GO:0004175 ISO     metalloendopeptidase activity GO:0004222 IBA     metalloendopeptidase activity GO:0004222 IDA     metalloendopeptidase activity GO:0004222 IEA     metalloendopeptidase activity GO:0004222 IMP     metalloendopeptidase activity GO:0004222 ISO     metalloendopeptidase activity GO:0004222 ISS     ATP binding GO:0005524 IEA     ATP binding GO:0005524 IMP     ATP binding GO:0005524 IPI     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     peptidase activity GO:0008233 TAS     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 IMP     zinc ion binding GO:0008270 ISO     zinc ion binding GO:0008270 ISS     ATP hydrolysis activity GO:0016887 IDA     peptide hormone binding GO:0017046 IPI     beta-endorphin binding GO:0031626 IMP     peptide binding GO:0042277 IEA     peptide binding GO:0042277 ISO     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     insulin binding GO:0043559 IEA     insulin binding GO:0043559 IMP     insulin binding GO:0043559 ISO     protein-containing complex binding GO:0044877 IDA     metal ion binding GO:0046872 IEA Biological Process     proteolysis GO:0006508 IEA     proteolysis GO:0006508 ISO     response to oxidative stress GO:0006979 ISO     bradykinin catabolic process GO:0010815 IEA     bradykinin catabolic process GO:0010815 ISO     bradykinin catabolic process GO:0010815 ISS     ubiquitin recycling GO:0010992 IEA     ubiquitin recycling GO:0010992 ISO     antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IEA     antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 ISO     antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 ISS     protein catabolic process GO:0030163 IDA     protein catabolic process GO:0030163 ISO     insulin receptor recycling GO:0038020 ISO     hormone catabolic process GO:0042447 IBA     hormone catabolic process GO:0042447 IDA     hormone catabolic process GO:0042447 IEA     hormone catabolic process GO:0042447 ISO     peptide catabolic process GO:0043171 IBA     peptide catabolic process GO:0043171 IEA     peptide catabolic process GO:0043171 ISO     peptide catabolic process GO:0043171 ISS     peptide catabolic process GO:0043171 TAS     negative regulation of proteolysis GO:0045861 IDA     amyloid-beta metabolic process GO:0050435 IBA     amyloid-beta metabolic process GO:0050435 IMP     amyloid-beta metabolic process GO:0050435 ISO     amyloid-beta metabolic process GO:0050435 ISS     proteolysis involved in protein catabolic process GO:0051603 IBA     proteolysis involved in protein catabolic process GO:0051603 IEA     proteolysis involved in protein catabolic process GO:0051603 IMP     proteolysis involved in protein catabolic process GO:0051603 ISO     amyloid-beta clearance GO:0097242 IGI     amyloid-beta clearance GO:0097242 IMP     amyloid-beta clearance GO:0097242 ISO     amyloid-beta clearance GO:0097242 ISO     amyloid-beta clearance by cellular catabolic process GO:0150094 IEA     amyloid-beta clearance by cellular catabolic process GO:0150094 IMP     amyloid-beta clearance by cellular catabolic process GO:0150094 ISO     insulin metabolic process GO:1901142 ISO     insulin catabolic process GO:1901143 IEA     insulin catabolic process GO:1901143 ISO     insulin catabolic process GO:1901143 ISS     regulation of aerobic respiration GO:1903715 IEA     regulation of aerobic respiration GO:1903715 ISO Subcellular Localization     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     peroxisome GO:0005777 IEA     peroxisome GO:0005777 ISO     peroxisomal matrix GO:0005782 IBA     peroxisomal matrix GO:0005782 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     external side of plasma membrane GO:0009897 IEA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     cytosolic proteasome complex GO:0031597 IDA     endosome lumen GO:0031904 ISO     extracellular exosome GO:0070062 ISO