Gene description for Ahr
Gene name aryl hydrocarbon receptor
Gene symbol Ahr
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ahr
ExoCarta ExoCarta_25690
Vesiclepedia VP_25690
Entrez Gene 25690
UniProt P41738  
 Ahr identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ahr
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IBA
    transcription cis-regulatory region binding GO:0000976 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    cis-regulatory region sequence-specific DNA binding GO:0000987 IEA
    cis-regulatory region sequence-specific DNA binding GO:0000987 ISO
    TFIID-class transcription factor complex binding GO:0001094 IEA
    TFIID-class transcription factor complex binding GO:0001094 ISO
    transcription coactivator binding GO:0001223 IEA
    transcription coactivator binding GO:0001223 ISO
    DNA binding GO:0003677 ISO
    DNA-binding transcription factor activity GO:0003700 ISO
    nuclear receptor activity GO:0004879 IDA
    nuclear receptor activity GO:0004879 IEA
    nuclear receptor activity GO:0004879 ISO
    nuclear receptor activity GO:0004879 ISO
    protein binding GO:0005515 IPI
    toxic substance binding GO:0015643 IDA
    TBP-class protein binding GO:0017025 IEA
    TBP-class protein binding GO:0017025 ISO
    aryl hydrocarbon receptor binding GO:0017162 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    sequence-specific DNA binding GO:0043565 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
    protein-folding chaperone binding GO:0051087 ISO
    Hsp90 protein binding GO:0051879 IEA
    Hsp90 protein binding GO:0051879 ISO
    arachidonate omega-hydroxylase activity GO:0052869 IMP
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
    E-box binding GO:0070888 ISO
    E-box binding GO:0070888 ISS
    sequence-specific double-stranded DNA binding GO:1990837 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IMP
    sequence-specific double-stranded DNA binding GO:1990837 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    cell morphogenesis GO:0000902 ISO
    ovarian follicle development GO:0001541 IMP
    blood vessel development GO:0001568 ISO
    branching involved in blood vessel morphogenesis GO:0001569 ISO
    conditioned taste aversion GO:0001661 IMP
    B cell homeostasis GO:0001782 ISO
    regulation of cytokine production GO:0001817 IMP
    liver development GO:0001889 ISO
    vasculature development GO:0001944 ISO
    blood vessel remodeling GO:0001974 ISO
    lymphocyte homeostasis GO:0002260 ISO
    immune system process GO:0002376 ISO
    regulation of adaptive immune response GO:0002819 ISO
    regulation of adaptive immune response GO:0002819 ISS
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 IEA
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 ISO
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 ISS
    negative regulation of systemic arterial blood pressure GO:0003085 ISO
    cardiac left ventricle morphogenesis GO:0003214 ISO
    circumferential growth involved in left ventricle morphogenesis GO:0003243 ISO
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    transcription by RNA polymerase II GO:0006366 IDA
    transcription by RNA polymerase II GO:0006366 ISO
    xenobiotic metabolic process GO:0006805 IEA
    apoptotic process GO:0006915 TAS
    female pregnancy GO:0007565 IEP
    circadian rhythm GO:0007623 IEP
    blood circulation GO:0008015 ISO
    response to xenobiotic stimulus GO:0009410 IDA
    response to xenobiotic stimulus GO:0009410 IEP
    response to xenobiotic stimulus GO:0009410 ISO
    response to toxic substance GO:0009636 IEA
    response to toxic substance GO:0009636 IEP
    response to toxic substance GO:0009636 ISO
    regulation of gene expression GO:0010468 ISO
    negative regulation of alkaline phosphatase activity GO:0010693 IDA
    response to organic cyclic compound GO:0014070 IEP
    response to organic cyclic compound GO:0014070 IMP
    estrogen receptor signaling pathway GO:0030520 IDA
    intracellular receptor signaling pathway GO:0030522 IEA
    prostate gland development GO:0030850 ISO
    regulation of B cell proliferation GO:0030888 IEA
    regulation of B cell proliferation GO:0030888 ISO
    response to estradiol GO:0032355 IEP
    circadian regulation of gene expression GO:0032922 ISO
    circadian regulation of gene expression GO:0032922 ISS
    negative regulation of osteoblast proliferation GO:0033689 IDA
    protein localization to nucleus GO:0034504 IMP
    post-embryonic hemopoiesis GO:0035166 ISO
    positive regulation of growth rate GO:0040010 ISO
    camera-type eye development GO:0043010 ISO
    T cell homeostasis GO:0043029 ISO
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of osteoblast differentiation GO:0045668 IDA
    positive regulation of cell size GO:0045793 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of mating-type specific transcription, DNA-templated GO:0045895 IDA
    positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 ISO
    negative regulation of vasoconstriction GO:0045906 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    nitric oxide metabolic process GO:0046209 IEP
    aflatoxin metabolic process GO:0046222 IEP
    response to arsenic-containing substance GO:0046685 IEP
    rhythmic process GO:0048511 IEA
    blood vessel morphogenesis GO:0048514 ISO
    spleen development GO:0048536 ISO
    reproductive structure development GO:0048608 ISO
    gland development GO:0048732 ISO
    tissue remodeling GO:0048771 IEP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    negative regulation of inflammatory response GO:0050728 IEA
    negative regulation of inflammatory response GO:0050728 ISO
    regulation of cell cycle GO:0051726 TAS
    contact inhibition GO:0060242 IMP
    mammary duct terminal end bud growth GO:0060763 IDA
    kidney morphogenesis GO:0060993 ISO
    cellular response to molecule of bacterial origin GO:0071219 IEA
    cellular response to molecule of bacterial origin GO:0071219 ISO
    cellular response to cAMP GO:0071320 IEA
    cellular response to cAMP GO:0071320 ISO
    cellular response to glucocorticoid stimulus GO:0071385 IEP
    cellular response to dexamethasone stimulus GO:0071549 IEP
    glomerulus morphogenesis GO:0072102 ISO
    cellular response to toxic substance GO:0097237 IMP
    omega-hydroxylase P450 pathway GO:0097267 IMP
    negative regulation of calcium ion transmembrane transport GO:1903170 IDA
    reactive oxygen species biosynthetic process GO:1903409 IMP
    regulation of eating behavior GO:1903998 IDA
    cellular response to forskolin GO:1904322 IEA
    cellular response to forskolin GO:1904322 ISO
    cellular response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904613 IDA
    cellular response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904613 IEA
    cellular response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904613 ISO
    cellular response to 3-methylcholanthrene GO:1904682 ISO
    negative regulation of DNA biosynthetic process GO:2000279 IDA
    negative regulation of DNA biosynthetic process GO:2000279 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    protein-containing complex GO:0032991 ISO
    aryl hydrocarbon receptor complex GO:0034751 IBA
    nuclear aryl hydrocarbon receptor complex GO:0034753 IEA
    nuclear aryl hydrocarbon receptor complex GO:0034753 ISO
    nuclear aryl hydrocarbon receptor complex GO:0034753 ISS
 Experiment description of studies that identified Ahr in sEVs
1
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ahr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hsp90aa1 299331
Affinity Capture-Western Rattus norvegicus
2 Aip  
Affinity Capture-Western Rattus norvegicus
3 Arnt  
Affinity Capture-Western Rattus norvegicus
4 Ubc  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Ahr is involved
No pathways found





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