Gene description for Fn1
Gene name fibronectin 1
Gene symbol Fn1
Other names/aliases FIBNEC
fn-1
Species Rattus norvegicus
 Database cross references - Fn1
ExoCarta ExoCarta_25661
Entrez Gene 25661
 Fn1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Fn1
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    protease binding GO:0002020 ISO
    mercury ion binding GO:0045340 IDA
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 TAS
    peptidase activator activity GO:0016504 ISO
Biological Process
    cell-substrate junction assembly GO:0007044 ISO
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEP
    acute-phase response GO:0006953 IEA
    cellular response to prostaglandin E stimulus GO:0071380 IEP
    cellular response to BMP stimulus GO:0071773 IEP
    integrin activation GO:0033622 ISO
    cellular response to mercury ion GO:0071288 IDA
    cell-matrix adhesion GO:0007160 ISO
    response to glucocorticoid GO:0051384 IEP
    peptide cross-linking GO:0018149 ISO
    response to ischemia GO:0002931 IEP
    cellular response to lipopolysaccharide GO:0071222 IEP
    response to wounding GO:0009611 IEP
    calcium-independent cell-matrix adhesion GO:0007161 ISO
    cell adhesion GO:0007155 ISO
    positive regulation of peptidase activity GO:0010952 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    response to ozone GO:0010193 IEP
    endodermal cell differentiation GO:0035987 ISO
    positive regulation of chemotaxis GO:0050921 IDA
    extracellular matrix organization GO:0030198 IMP
    angiogenesis GO:0001525 IEA
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of axon extension GO:0045773 ISO
    glial cell migration GO:0008347 IDA
    regulation of cell shape GO:0008360 IEA
    ossification GO:0001503 TAS
    cell activation GO:0001775 IMP
    wound healing GO:0042060 ISO
    cellular response to glucose stimulus GO:0071333 IEP
    cellular response to interleukin-1 GO:0071347 IMP
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IEP
    negative regulation of apoptotic process GO:0043066 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    basal lamina GO:0005605 ISO
    fibrinogen complex GO:0005577 ISO
    apical plasma membrane GO:0016324 ISO
    extracellular exosome GO:0070062 ISO
    extracellular matrix GO:0031012 ISO
    basement membrane GO:0005604 ISO
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    extracellular space GO:0005615 ISO
    proteinaceous extracellular matrix GO:0005578 TAS
    blood microparticle GO:0072562 ISO
 Experiment description of studies that identified Fn1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Fn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fn1 is involved
No pathways found





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