Gene description for Khk
Gene name ketohexokinase
Gene symbol Khk
Other names/aliases KETHPRO
Species Rattus norvegicus
 Database cross references - Khk
ExoCarta ExoCarta_25659
Entrez Gene 25659
UniProt Q02974  
 Khk identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Khk
Molecular Function
    fructokinase activity GO:0008865 ISO
    ATP binding GO:0005524 IEA
    ketohexokinase activity GO:0004454 TAS
Biological Process
    fructose metabolic process GO:0006000 ISO
    response to zinc ion GO:0010043 IDA
    response to sucrose GO:0009744 IDA
    regulation of glycogen metabolic process GO:0070873 ISO
    response to glucose GO:0009749 IDA
    response to insulin GO:0032868 IDA
    carbohydrate phosphorylation GO:0046835 ISO
    response to fructose GO:0009750 IEP
    carbohydrate catabolic process GO:0016052 TAS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    cellular_component GO:0005575 ND
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Khk in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Khk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Khk is involved
No pathways found





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