Gene description for Cd81
Gene name Cd81 molecule
Gene symbol Cd81
Other names/aliases Tapa1
Species Rattus norvegicus
 Database cross references - Cd81
ExoCarta ExoCarta_25621
Entrez Gene 25621
UniProt Q62745  
 Cd81 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cd81
Molecular Function
    MHC class II protein complex binding GO:0023026 ISO
    protein binding GO:0005515 IPI
Biological Process
    activation of MAPK activity GO:0000187 ISS
    positive regulation of cell proliferation GO:0008284 ISS
    phosphatidylinositol metabolic process GO:0046488 ISS
    protein localization GO:0008104 ISS
    regulation of cell motility GO:2000145 ISO
    regulation of cell proliferation GO:0042127 IDA
    response to wounding GO:0009611 IEP
    regulation of growth GO:0040008 IEP
    positive regulation of 1-phosphatidylinositol 4-kinase activity GO:0043128 ISS
    positive regulation of B cell proliferation GO:0030890 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
    phosphatidylinositol biosynthetic process GO:0006661 ISS
Subcellular Localization
    apical plasma membrane GO:0016324 IDA
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 ISO
    integral component of plasma membrane GO:0005887 ISS
    immunological synapse GO:0001772 ISO
    vesicle GO:0031982 ISO
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IDA
 Experiment description of studies that identified Cd81 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cd81
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd81 is involved
No pathways found





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