Gene description for Alpl
Gene name	alkaline phosphatase, liver/bone/kidney
Gene symbol	Alpl
Other names/aliases	Akp2 PHOA
Species	Rattus norvegicus
Database cross references - Alpl
ExoCarta	ExoCarta_25586
Vesiclepedia	VP_25586
Entrez Gene	25586
UniProt	P08289
Alpl identified in sEVs derived from the following tissue/cell type
Urine	20535238

Gene ontology annotations for Alpl

Molecular Function     DNA clamp loader activity GO:0003689 IEA     alkaline phosphatase activity GO:0004035 IBA     alkaline phosphatase activity GO:0004035 IDA     alkaline phosphatase activity GO:0004035 ISO     alkaline phosphatase activity GO:0004035 TAS     inorganic diphosphate phosphatase activity GO:0004427 IEA     calcium ion binding GO:0005509 ISO     calcium ion binding GO:0005509 ISS     pyrophosphatase activity GO:0016462 ISO     pyrophosphatase activity GO:0016462 ISS     ATP hydrolysis activity GO:0016887 IEA     pyridoxal phosphatase activity GO:0033883 ISO     pyridoxal phosphatase activity GO:0033883 ISS     ADP phosphatase activity GO:0043262 IEA     phosphoamidase activity GO:0050187 ISO     phosphoamidase activity GO:0050187 ISS     phosphoethanolamine phosphatase activity GO:0052732 ISO     cohesin loader activity GO:0061775 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA Biological Process     endochondral ossification GO:0001958 ISO     developmental process involved in reproduction GO:0003006 ISO     chromatin remodeling GO:0006338 IEA     response to organic cyclic compound GO:0014070 IEP     cellular homeostasis GO:0019725 ISO     bone mineralization GO:0030282 ISO     bone mineralization GO:0030282 ISS     biomineral tissue development GO:0031214 IBA     response to lipopolysaccharide GO:0032496 IEP     response to insulin GO:0032868 IEP     response to vitamin D GO:0033280 ISO     response to vitamin B6 GO:0034516 ISO     response to macrophage colony-stimulating factor GO:0036005 IEP     pyridoxal phosphate metabolic process GO:0042822 ISO     response to antibiotic GO:0046677 ISO     response to glucocorticoid GO:0051384 IDA     phosphate ion homeostasis GO:0055062 ISO     calcium ion homeostasis GO:0055074 ISO     cellular response to organic cyclic compound GO:0071407 ISO     cementum mineralization GO:0071529 IEP     positive regulation of cold-induced thermogenesis GO:0120162 ISO     positive regulation of cold-induced thermogenesis GO:0120162 ISS     chromatin looping GO:0140588 IEA     futile creatine cycle GO:0140651 ISO     inhibition of non-skeletal tissue mineralization GO:0140928 ISO     response to sodium phosphate GO:1904383 ISO Subcellular Localization     extracellular space GO:0005615 IDA     mitochondrial intermembrane space GO:0005758 ISO     mitochondrial intermembrane space GO:0005758 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     extracellular matrix GO:0031012 ISO     mitochondrial membrane GO:0031966 ISO     mitochondrial membrane GO:0031966 ISS     extracellular membrane-bounded organelle GO:0065010 IDA     extracellular membrane-bounded organelle GO:0065010 ISO     side of membrane GO:0098552 IEA