Gene description for Slc6a4
Gene name	solute carrier family 6 (neurotransmitter transporter), member 4
Gene symbol	Slc6a4
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Slc6a4
ExoCarta	ExoCarta_25553
Vesiclepedia	VP_25553
Entrez Gene	25553
UniProt	P31652
Slc6a4 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Slc6a4

Molecular Function     integrin binding GO:0005178 ISO     integrin binding GO:0005178 ISS     monoatomic cation channel activity GO:0005261 IDA     neurotransmitter transmembrane transporter activity GO:0005326 ISO     serotonin:sodium:chloride symporter activity GO:0005335 IBA     serotonin:sodium:chloride symporter activity GO:0005335 IDA     serotonin:sodium:chloride symporter activity GO:0005335 IMP     serotonin:sodium:chloride symporter activity GO:0005335 ISO     serotonin:sodium:chloride symporter activity GO:0005335 TAS     protein binding GO:0005515 IPI     monoamine transmembrane transporter activity GO:0008504 ISO     antiporter activity GO:0015297 ISO     syntaxin-1 binding GO:0017075 IPI     cocaine binding GO:0019811 IMP     sodium ion binding GO:0031402 ISO     sodium ion binding GO:0031402 ISS     identical protein binding GO:0042802 IPI     nitric-oxide synthase binding GO:0050998 ISO     actin filament binding GO:0051015 IDA     serotonin binding GO:0051378 IBA     serotonin binding GO:0051378 ISO     serotonin binding GO:0051378 ISS Biological Process     response to hypoxia GO:0001666 IEP     neurotransmitter transport GO:0006836 ISO     serotonin transport GO:0006837 IDA     serotonin transport GO:0006837 IMP     serotonin transport GO:0006837 ISO     serotonin transport GO:0006837 TAS     amino acid transport GO:0006865 IBA     response to nutrient GO:0007584 IEP     memory GO:0007613 IMP     circadian rhythm GO:0007623 IMP     locomotory behavior GO:0007626 NAS     response to xenobiotic stimulus GO:0009410 IEP     response to toxic substance GO:0009636 ISO     positive regulation of gene expression GO:0010628 ISO     positive regulation of serotonin secretion GO:0014064 IMP     monoamine transport GO:0015844 ISO     negative regulation of cerebellar granule cell precursor proliferation GO:0021941 IMP     negative regulation of synaptic transmission, dopaminergic GO:0032227 IMP     response to estradiol GO:0032355 IEP     sodium ion transmembrane transport GO:0035725 IBA     vasoconstriction GO:0042310 IMP     negative regulation of neuron differentiation GO:0045665 IMP     positive regulation of cell cycle GO:0045787 ISO     negative regulation of organ growth GO:0046621 ISO     behavioral response to cocaine GO:0048148 IMP     enteric nervous system development GO:0048484 ISO     brain morphogenesis GO:0048854 ISO     serotonin uptake GO:0051610 IBA     serotonin uptake GO:0051610 IDA     serotonin uptake GO:0051610 ISO     membrane depolarization GO:0051899 IDA     male mating behavior GO:0060179 IMP     platelet aggregation GO:0070527 ISO     platelet aggregation GO:0070527 ISS     cellular response to retinoic acid GO:0071300 IEP     cellular response to cGMP GO:0071321 IDA     regulation of thalamus size GO:0090067 ISO     regulation of thalamus size GO:0090067 ISS     neurotransmitter reuptake GO:0098810 ISO     conditioned place preference GO:1990708 IMP Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 ISO     focal adhesion GO:0005925 ISS     endosome membrane GO:0010008 IEA     endomembrane system GO:0012505 IDA     endomembrane system GO:0012505 ISO     endomembrane system GO:0012505 NAS     presynaptic membrane GO:0042734 IDA     neuron projection GO:0043005 IBA     membrane raft GO:0045121 ISO     synapse GO:0045202 IBA     synapse GO:0045202 ISO     synapse GO:0045202 ISS     postsynaptic membrane GO:0045211 IDA     serotonergic synapse GO:0099154 IDA